Although much effort has been devoted to determine the 3D structure of chromatin, there is a need for new experimental and computational methods. Here the authors present GP-FBM to extract chromatin diffusion parameters with high precision and apply it to live-imaging of embryonic stem cells, revealing that the diffusive properties of mitotic and interphase chromatin do not differ significantly.
- Guilherme M. Oliveira
- Attila Oravecz
- Nacho Molina
