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Author Correction: Robust and tunable signal processing in mammalian cells via engineered covalent modification cycles

Ross D. Jones
Yili Qian
Ron Weiss
Amendments and CorrectionsOpen Access08 Aug 2023
Nature Communications

Volume: 14, P: 1-2
Feedforward growth rate control mitigates gene activation burden

Heterologous gene activation causes non-physiological burden on cellular resources that cells are unable to adjust to. Here the authors present a tunable, modular, and portable feedforward controller that allows dynamic modulation of a genes expression to possibly high-levels without substantially affecting growth rate.

Carlos Barajas
Hsin-Ho Huang
Domitilla Del Vecchio
ResearchOpen Access17 Nov 2022
Nature Communications

Volume: 13, P: 1-10
dCas9 regulator to neutralize competition in CRISPRi circuits

CRISPRi allows for the simultaneous control of many genes, however the sgRNAs compete for binding to dCas9. Here the authors design a dCas9 concentration regulator to allow independent regulation of multiple genes.

Hsin-Ho Huang
Massimo Bellato
Domitilla Del Vecchio
ResearchOpen Access16 Mar 2021
Nature Communications

Volume: 12, P: 1-7
A quasi-integral controller for adaptation of genetic modules to variable ribosome demand

Competition for shared cellular resources often renders genetic circuits poorly predictable. Here the authors design a biomolecular quasi-integral controller that allows gene expression to adapt to variable demand in translation resources.

Hsin-Ho Huang
Yili Qian
Domitilla Del Vecchio
ResearchOpen Access21 Dec 2018
Nature Communications

Volume: 9, P: 1-12
Robust and tunable signal processing in mammalian cells via engineered covalent modification cycles

Phosphorylation networks are frequently at the heart of complex cellular decision making. Here the authors engineer synthetic phosphorylation devices with feedback regulation in mammalian cells and demonstrate how to use these to achieve tunable and robust control of cell behaviours.

Ross D. Jones
Yili Qian
Ron Weiss
ResearchOpen Access31 Mar 2022
Nature Communications

Volume: 13, P: 1-17
An endoribonuclease-based feedforward controller for decoupling resource-limited genetic modules in mammalian cells

Accurately predicting the behaviour of a genetic circuit remains difficult due to the lack of modularity. Here the authors quantify the effects of resource loading in mammalian systems and develop an endoribonuclease-based feedfoward controller to adapt gene expression to the effects of resource loading.

Ross D. Jones
Yili Qian
Domitilla Del Vecchio
ResearchOpen Access10 Nov 2020
Nature Communications

Volume: 11, P: 1-16
A load driver device for engineering modularity in biological networks

Including a load driver in a modular genetic circuit abrogates the effect of downstream elements that can interfere with circuit performance.

Deepak Mishra
Phillip M Rivera
Ron Weiss
Research24 Nov 2014
Nature Biotechnology

Volume: 32, P: 1268-1275
Epigenetic OCT4 regulatory network: stochastic analysis of cellular reprogramming

Simone Bruno
Thorsten M. Schlaeger
Domitilla Del Vecchio
ResearchOpen Access06 Jan 2024
npj Systems Biology and Applications

Volume: 10, P: 1-10

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