Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–6 of 6 results
Advanced filters: Author: Donald Tweedie Clear advanced filters

  • Membrane transporters play an important part in determining the pharmacokinetics of many drugs. Here, the International Transporter Consortium discusses key transporters with a role in drug absorption and disposition, and provides guidance for clinical drug interaction studies.

    • Kathleen M. Giacomini
    • Shiew-Mei Huang
    • Lei Zhang
    Reviews
    Nature Reviews Drug Discovery
    Volume: 9, P: 215-236

  • Chemically reactive metabolites (CRMs) can initiate serious adverse drug reactions. In their Review, Park and colleagues discuss current approaches for the evaluation of CRMs and examine how this knowledge can inform the various stages of the drug discovery and development process.

    • B. Kevin Park
    • Alan Boobis
    • Thomas A. Baillie
    Reviews
    Nature Reviews Drug Discovery
    Volume: 10, P: 292-306

  • Significant progress has been made in understanding the influence of membrane transporters in drug disposition and response. Here, the International Transporter Consortium provides an update on the current status of membrane transporters in drug development and regulatory requirements, discusses recent scientific advances in the field and highlights future directions and unanswered questions.

    • Aleksandra Galetin
    • Kim L. R. Brouwer
    • Kathleen M. Giacomini
    Reviews
    Nature Reviews Drug Discovery
    Volume: 23, P: 255-280

  • As tundra ecosystems respond to rapid Arctic warming, satellite records suggest a widespread greening. This Perspective highlights the challenges of interpreting complex Arctic greening trends and provides direction for future research by combining ecological and remote sensing approaches.

    • Isla H. Myers-Smith
    • Jeffrey T. Kerby
    • Sonja Wipf
    Reviews
    Nature Climate Change
    Volume: 10, P: 106-117