Zika virus poses a potential threat to male reproductive health but the underlying mechanisms remain obscure. To address this question, the study by Yang et al performs single-cell RNA sequencing with ZIKV-infected mice testes. The authors find that spermatogenic cells are fragile to ZIKV infection and the complement system components produced by infiltrated S100A4 + monocytes/macrophages are crucial for the injury of spermatogenic cells.
- Wei Yang
- Li-Bo Liu
- Pei-Gang Wang
