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Showing 1–14 of 14 results
Advanced filters: Author: Dongchun Ni Clear advanced filters

  • The histone deacylase SIRT7 regulates gene expression via highly specific activity on chromatin substrates. Moreno-Yruela et al. provide cryo-EM structures and identify the mechanisms of substrate specificity and a unique nucleosome-binding domain.

    • Carlos Moreno-Yruela
    • Babatunde E. Ekundayo
    • Beat Fierz
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • The structure of a bacterial membrane protein complex involved in the bioremediation of tetrachloroethene, a major chlorinated organic pollutant, was determined. It elucidates the path of electrons from menaquinol to the active site of the enzyme.

    • Lorenzo Cimmino
    • Américo G. Duarte
    • Julien Maillard
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-11

  • This work provides molecular insights into the export of cyclic glucans by a bacterial ABC transporter. The findings expand our understanding of polysaccharide trafficking across bacterial membranes, as well as protein-sugar interactions in general.

    • Jaroslaw Sedzicki
    • Dongchun Ni
    • Christoph Dehio
    Research
    Nature Structural & Molecular Biology
    Volume: 29, P: 1170-1177

  • Lateral opening of the LptDE transporter in the outer membrane of Gram-negative bacteria is necessary for insertion of lipopolysaccharides. Here, Botte et al. report a cryo-EM structure of a partially opened LptDE transporter, in complex with rigid chaperones derived from nanobodies.

    • Mathieu Botte
    • Dongchun Ni
    • Michael Hennig
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10

  • BSEP (ABCB11) is expressed in hepatocytes and extrudes bile salts into the canaliculi of the liver. Here, authors report cryo-EM structures of BSEP providing structural and functional insight into the mechanism of bile salt extrusion and small-molecule inhibition.

    • Hongtao Liu
    • Rossitza N. Irobalieva
    • Kaspar P. Locher
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12

  • Here the authors use cryo-EM and biochemical analysis to show how the ancillary protein TPR-CHAT regulates the nuclease function of the CRISPR-guided nuclease Cas7-11.

    • Babatunde Ekundayo
    • Davide Torre
    • Dongchun Ni
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 30, P: 135-139

  • TRPM4 is an ion channel associated with various genetic and cardiovascular disorders. The authors utilized cryo-EM and patch clamp experiments to determine the binding sites of potent and specific TRPM4 inhibitors driving further drug development targeting TRPM4.

    • Babatunde Ekundayo
    • Prakash Arullampalam
    • Dongchun Ni
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • A surface-centric approach captures the physical and chemical determinants of molecular recognition, enabling the de novo design of protein interactions and of artificial proteins with function.

    • Pablo Gainza
    • Sarah Wehrle
    • Bruno E. Correia
    ResearchOpen Access
    Nature
    Volume: 617, P: 176-184

  • Certain bats species have previously been identified as ancestral sources of coronaviruses that infect humans but there is limited data on the genomic diversity or zoonotic potential of viruses infecting bats in the UK. Here, the authors use deep sequencing and in vitro assays to characterise coronaviruses recovered from 48 bat faecal samples.

    • Cedric C. S. Tan
    • Jahcub Trew
    • Vincent Savolainen
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • ABCG2 is a transporter contributing to multidrug resistance of cancer cells. Here, structures of human ABCG2 under turnover conditions reveal distinct conformational states, provide insight into the transport cycle and suggest a mechanism of discrimination between substrates and inhibitors.

    • Qin Yu
    • Dongchun Ni
    • Kaspar P. Locher
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12