Traditional N-alkylation methods, especially for α-tertiary amines, suffer from limitations due to high energy barriers from steric hindrance. In this work, the authors leverage visible light irradiation to enable organoboronic acid addition to sterically hindered ketimines using a three-component coupling of aliphatic amines, ortho-phenolic ketones, and organoboronic acids.
- Peng Zou
- Dongmin Fu
- Yiyun Chen
