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Showing 1–2 of 2 results
Advanced filters: Author: Dongzheng Gai Clear advanced filters

  • BCMA-specific CAR T-cell therapies have shown high response rates in multiple myeloma (MM), however the majority of patients still relapse. Here the authors show that CD24-positive MM cells increase after BCMA-CAR-T treatment in patients, and that dual-targeted BCMA/CD24 CAR-T cells can improve anti-tumor efficacy in MM preclinical models.

    • Fumou Sun
    • Yan Cheng
    • Fenghuang Zhan
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • Chen et al. show that hippuric acid (HA), which is a diet-derived phenolic acid, inhibits bone resorption and increases bone mass in wild type mice, but not in G-protein coupled receptor (GPR109A) knockout mice. This study suggests that GPR109A mediates the effects of HA on inhibiting bone resorption during skeletal development.

    • Jin-Ran Chen
    • Haijun Zhao
    • Oxana P. Lazarenko
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-12