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Showing 1–4 of 4 results
Advanced filters: Author: Dorian V. Ziegler Clear advanced filters

  • CDK4/6 inhibitors (CDK4/6i) have improved cancer patient outcomes but shown limited benefits for those with triple-negative breast cancer (TNBC). Here, the authors report that CDK4/6 inhibition prevents CDK4 enhanced mitochondria-endoplasmic reticulum interactions, inhibiting mitochondrial apoptosis and driving resistance to CDK4/6i in TNBC models.

    • Dorian V. Ziegler
    • Kanishka Parashar
    • Lluis Fajas
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-23

  • Contacts between mitochondria and endoplasmatic reticulum (ER), and the transfer of calcium between them, have an important role in the regulation of cellular phenotypes, including senescence. Here the authors show that ITPR2 deficient mice display improved aging, associated with a decreased number of contacts between the mitochondria and the ER.

    • Dorian V. Ziegler
    • David Vindrieux
    • David Bernard
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • This perspective by Ziegler et al. explores the impact of mitochondria-endoplasmic reticulum contacts (MERCs) biology on cellular senescence. The authors also explore the potential impacts of MERCs perturbation and how this relates to the increase in cellular senescence observed in common age-related diseases.

    • Dorian V. Ziegler
    • Nadine Martin
    • David Bernard
    ReviewsOpen Access
    Communications Biology
    Volume: 4, P: 1-14