Glucose from excess dietary carbohydrate is converted to fatty acids in the liver throughde novolipogenesis. Lipogenic genes have common features in their promoters and are coordinately regulated at the transcriptional level. Recent insights have been gained into the signalling pathways that regulate key transcription factors such as USFs, SREBP1C, LXRs and ChREBP.
- Yuhui Wang
- Jose Viscarra
- Hei Sook Sul
