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Molecular Psychiatry (2)
Nature Chemical Biology (2)

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Showing 1–4 of 4 results

Advanced filters: Author: Dorit Trudler Clear advanced filters

Targeted protein S-nitrosylation of ACE2 inhibits SARS-CoV-2 infection

Aminoadamantane compounds, delivered to cells via binding to viroporin channels, induce S-nitrosylation of the ACE2 protein, inhibiting binding to SARS-CoV-2 spike protein and viral infection.

Chang-ki Oh
Tomohiro Nakamura
Stuart A. Lipton
Research29 Sept 2022
Nature Chemical Biology

Volume: 19, P: 275-283
Dysregulation of miRNA expression and excitation in MEF2C autism patient hiPSC-neurons and cerebral organoids

Dorit Trudler
Swagata Ghatak
Stuart A. Lipton
ResearchOpen Access30 Sept 2024
Molecular Psychiatry

Volume: 30, P: 1479-1496
Phenylalanine assembly into toxic fibrils suggests amyloid etiology in phenylketonuria

Phenylketonuria (PKU) is characterized by increased levels of phenylalanine in the blood and progressive mental retardation. Now, phenylalanine is shown to form toxic amyloid fibrils at high concentrations, which accumulate in the brains of PKU patients and mouse models.

Lihi Adler-Abramovich
Lilach Vaks
Ehud Gazit
Research17 Jun 2012
Nature Chemical Biology

Volume: 8, P: 701-706
NitroSynapsin ameliorates hypersynchronous neural network activity in Alzheimer hiPSC models

Swagata Ghatak
Nima Dolatabadi
Stuart A. Lipton
Research29 May 2020
Molecular Psychiatry

Volume: 26, P: 5751-5765