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Showing 1–5 of 5 results
Advanced filters: Author: Dorothée Diogo Clear advanced filters

  • Testing the association between genetic variants and a range of phenotypes can assist drug development. Here, in a phenome-wide association study in up to 697,815 individuals, Diogo et al. identify genotype–phenotype associations predicting efficacy, alternative indications or adverse drug effects.

    • Dorothée Diogo
    • Chao Tian
    • Heiko Runz
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13

  • Jane Worthington and colleagues use a high-density genotyping chip to identify new susceptibility loci for rheumatoid arthritis and examine genetic overlap with other autoimmune diseases. Their results increase the number of confirmed rheumatoid arthritis risk loci in individuals of European ancestry and refine the location of many previously identified association signals to single genes.

    • Steve Eyre
    • John Bowes
    • Jane Worthington
    Research
    Nature Genetics
    Volume: 44, P: 1336-1340

  • The fungal pathogen Candida albicans can undergo a parasexual process that may contribute to genetic diversity, but its actual relevance is unclear. Here, Ropars et al. analyse the genomic sequences of 182 C. albicans isolates collected worldwide and find evidence of gene flow and thus parasexuality in nature.

    • Jeanne Ropars
    • Corinne Maufrais
    • Christophe d’Enfert
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • A genome-wide association study meta-analysis of more than 100,000 subjects of European and Asian ancestries reveals 42 new risk loci for rheumatoid arthritis, with follow-up studies identifying 98 biological candidate genes that are either already being targeted by drugs or could be in the future.

    • Yukinori Okada
    • Di Wu
    • Robert M. Plenge
    Research
    Nature
    Volume: 506, P: 376-381

  • Studies of human genetics have been used to identify promising drug targets, and might also inform safety assessment in the drug discovery process. In their Review, Ward and co-authors from industry discuss how genetic studies of rare and complex human diseases can be used to predict potential on- and off-target effects associated with modulating a given target. They also outline suggested best practices for incorporating human genetic data into safety assessments during drug development.

    • Keren J. Carss
    • Aimee M. Deaton
    • Jing Yuan
    Reviews
    Nature Reviews Drug Discovery
    Volume: 22, P: 145-162