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Showing 1–3 of 3 results
Advanced filters: Author: Dorte Bjerre Steensgaard Clear advanced filters

  • In this work, the authors described how the enhanced disulphide bond stability of insulin icodec enables its once-weekly profile. Disulphide bonds in insulin are subject to thiol-disulphide exchange in plasma leading to splitting insulin into its inactive chains, making the insulin disulfide stability crucial for its long duration of action.

    • František Hubálek
    • Christian N. Cramer
    • Thomas B. Kjeldsen
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-11

  • Recently, the first orally-administered ultra-long acting insulin was shown to have clinical efficacy. Here, the authors report the molecular engineering, as well as the biological and pharmacological properties of these insulin analogues.

    • Frantisek Hubálek
    • Hanne H. F. Refsgaard
    • Thomas Kjeldsen
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-9