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Showing 1–13 of 13 results
Advanced filters: Author: Doug Bonn Clear advanced filters

  • Neurological disorders such as temporal lobe epilepsy (TLE) are known to be regulated by gene networks. In this study, the authors describe a genome-wide approach that uses samples of hippocampal tissue from patients with TLE, to identify the gene Sestrin 3 (SESN3) as a positive regulator of the disease.

    • Michael R. Johnson
    • Jacques Behmoaras
    • Enrico Petretto
    Research
    Nature Communications
    Volume: 6, P: 1-11

  • Small structural distortions may lead to dramatic modification in the electronic states in strong correlated materials. Here, Yim et al. image a strain-stabilized smectic electronic order in LiFeAs with both broken rotational symmetry and reduced translational symmetry.

    • Chi Ming Yim
    • Christopher Trainer
    • Peter Wahl
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-7

  • Epilepsies are common brain disorders and are classified based on clinical phenotyping, imaging and genetics. Here, the authors perform genome-wide association studies for 3 broad and 7 subtypes of epilepsy and identify 16 loci - 11 novel - that are further annotated by eQTL and partitioned heritability analyses.

    • Bassel Abou-Khalil
    • Pauls Auce
    • Fritz Zimprich
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15

  • Impairment of cognitive function is a common feature of many neurodevelopmental disorders. Systems genetics analysis in the brain uncovered a convergent gene network for both cognition and neurodevelopmental disorders. As the network does not recapitulate known pathways, this finding represents a new basis for understanding factors influencing normal and disordered cognition.

    • Michael R Johnson
    • Kirill Shkura
    • Enrico Petretto
    Research
    Nature Neuroscience
    Volume: 19, P: 223-232

  • FlyWire presents a neuronal wiring diagram of the whole fly brain with annotations for cell types, classes, nerves, hemilineages and predicted neurotransmitters, with data products and an open ecosystem to facilitate exploration and browsing.

    • Sven Dorkenwald
    • Arie Matsliah
    • Meet Zandawala
    ResearchOpen Access
    Nature
    Volume: 634, P: 124-138

  • Production of reactive oxygen species is an ancient antimicrobial mechanism, but its role in antiviral defense in mammals is unclear. Here, To et al. show that virus infection activates endosomal NOX2 oxidase and restricts TLR7 signaling, and that an endosomal NOX2 inhibitor decreases viral pathogenicity.

    • Eunice E. To
    • Ross Vlahos
    • Stavros Selemidis
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-17

  • The accretion geometry of X-ray binary Cygnus X-3 is determined here from IXPE observations. X-ray polarization reveals a narrow funnel with reflecting walls, which focuses emission, making Cyg X-3 appear as an ultraluminous X-ray source.

    • Alexandra Veledina
    • Fabio Muleri
    • Silvia Zane
    Research
    Nature Astronomy
    Volume: 8, P: 1031-1046

  • Oropetium thomaeum is a resurrection plant that can survive extreme water stress through desiccation to complete dryness, providing a model for drought tolerance; here, whole-genome sequencing and assembly of the Oropetium genome using single-molecule real-time sequencing is reported.

    • Robert VanBuren
    • Doug Bryant
    • Todd C. Mockler
    ResearchOpen Access
    Nature
    Volume: 527, P: 508-511