Nature Search

Whole-brain annotation and multi-connectome cell typing of Drosophila

A consensus cell type atlas for the fly brain provides both an intellectual framework and open-source toolchains for brain-scale comparative connectomics.

Philipp Schlegel
Yijie Yin
Gregory S. X. E. Jefferis
ResearchOpen Access02 Oct 2024
Nature

Volume: 634, P: 139-152
Dysregulated ribonucleoprotein granules promote cardiomyopathy in RBM20 gene-edited pigs

Dysregulation of ribonucleoprotein complex granules, previously implicated in neuromuscular disease, can drive pathogenesis in a genetic form of dilated cardiomyopathy, as shown in gene-edited pigs and patient-derived cardiomyocytes.

Jay W. Schneider
Saji Oommen
Janell K. Fox
Research13 Nov 2020
Nature Medicine

Volume: 26, P: 1788-1800
Genetic risk of chronic pain conditions associated with risk of suicide death through an integrative analysis of EHR and genomics data

Seonggyun Han
Emily DiBlasi
Anna R. Docherty
ResearchOpen Access16 Feb 2026
Translational Psychiatry

Volume: 16, P: 1-10
Observation of constructive interference at the edge of quantum ergodicity

Experimental measurements of high-order out-of-time-order correlators on a superconducting quantum processor show that these correlators remain highly sensitive to the quantum many-body dynamics in quantum computers at long timescales.

Dmitry A. Abanin
Rajeev Acharya
Nicholas Zobrist
ResearchOpen Access22 Oct 2025
Nature

Volume: 646, P: 825-830
Neuronal wiring diagram of an adult brain

FlyWire presents a neuronal wiring diagram of the whole fly brain with annotations for cell types, classes, nerves, hemilineages and predicted neurotransmitters, with data products and an open ecosystem to facilitate exploration and browsing.

Sven Dorkenwald
Arie Matsliah
Meet Zandawala
ResearchOpen Access02 Oct 2024
Nature

Volume: 634, P: 124-138
Time-crystalline eigenstate order on a quantum processor

A study establishes a scalable approach to engineer and characterize a many-body-localized discrete time crystal phase on a superconducting quantum processor.

Xiao Mi
Matteo Ippoliti
Pedram Roushan
ResearchOpen Access30 Nov 2021
Nature

Volume: 601, P: 531-536
Quantum approximate optimization of non-planar graph problems on a planar superconducting processor

It is hoped that quantum computers may be faster than classical ones at solving optimization problems. Here the authors implement a quantum optimization algorithm over 23 qubits but find more limited performance when an optimization problem structure does not match the underlying hardware.

Matthew P. Harrigan
Kevin J. Sung
Ryan Babbush
Research04 Feb 2021
Nature Physics

Volume: 17, P: 332-336
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Sera from vaccinated individuals and some monoclonal antibodies show a modest reduction in neutralizing activity against the B.1.1.7 variant of SARS-CoV-2; but the E484K substitution leads to a considerable loss of neutralizing activity.

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Research11 Mar 2021
Nature

Volume: 593, P: 136-141
Quantum error correction below the surface code threshold

Two below-threshold surface code memories on superconducting processors markedly reduce logical error rates, achieving high efficiency and real-time decoding, indicating potential for practical large-scale fault-tolerant quantum algorithms.

Rajeev Acharya
Dmitry A. Abanin
Nicholas Zobrist
ResearchOpen Access09 Dec 2024
Nature

Volume: 638, P: 920-926
Integrated genomic and molecular characterization of cervical cancer

This paper describes molecular subtypes of cervical cancers, including squamous cell carcinoma and adenocarcinoma clusters defined by HPV status and molecular features, and distinct molecular pathways that are activated in cervical carcinomas caused by different somatic alterations and HPV types.

Robert D. Burk
Zigui Chen
David Mutch
ResearchOpen Access23 Jan 2017
Nature

Volume: 543, P: 378-384
SARS-CoV-2 evolution during treatment of chronic infection

Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Research05 Feb 2021
Nature

Volume: 592, P: 277-282
Expanded encyclopaedias of DNA elements in the human and mouse genomes

The authors summarize the data produced by phase III of the Encyclopedia of DNA Elements (ENCODE) project, a resource for better understanding of the human and mouse genomes.

Federico Abascal
Reyes Acosta
Zhiping Weng
ResearchOpen Access29 Jul 2020
Nature

Volume: 583, P: 699-710
Getting into the fold

Pharmacological chaperones are small molecules that interact with a protein to enhance folding and stability. Understanding the chemistry underlying the interaction of pharmacological chaperones with their target proteins will facilitate the design of more efficient drugs with greater therapeutic potential.

Doug A Brooks
News & Views01 Feb 2007
Nature Chemical Biology

Volume: 3, P: 84-85
Genomic reconstruction of the SARS-CoV-2 epidemic in England

A study of the evolution of the SARS-CoV-2 virus in England between September 2020 and June 2021 finds that interventions capable of containing previous variants were insufficient to stop the more transmissible Alpha and Delta variants.

Harald S. Vöhringer
Theo Sanderson
Moritz Gerstung
ResearchOpen Access14 Oct 2021
Nature

Volume: 600, P: 506-511
Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy

Production of reactive oxygen species is an ancient antimicrobial mechanism, but its role in antiviral defense in mammals is unclear. Here, To et al. show that virus infection activates endosomal NOX2 oxidase and restricts TLR7 signaling, and that an endosomal NOX2 inhibitor decreases viral pathogenicity.

Eunice E. To
Ross Vlahos
Stavros Selemidis
ResearchOpen Access12 Jul 2017
Nature Communications

Volume: 8, P: 1-17
Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas

Matthew Meyerson, Ramaswamy Govindan and colleagues examine the exome sequences and copy number profiles of 660 lung adenocarcinoma and 484 lung squamous cell carcinoma tumors. They identify novel significantly mutated genes and amplification peaks and find that around half of the tumors have at least five predicted neoepitopes.

Joshua D Campbell
Anton Alexandrov
Matthew Meyerson
Research09 May 2016
Nature Genetics

Volume: 48, P: 607-616
Comprehensive molecular characterization of gastric adenocarcinoma

The Cancer Genome Atlas reports on molecular evaluation of 295 primary gastric adenocarcinomas and proposes a new classification of gastric cancers into 4 subtypes, which should help with clinical assessment and trials of targeted therapies.

Adam J. Bass
Vesteinn Thorsson
Jia Liu
ResearchOpen Access23 Jul 2014
Nature

Volume: 513, P: 202-209
Integrated genomic characterization of oesophageal carcinoma

The Cancer Genome Atlas Research Network report integrated genomic and molecular analyses of 164 squamous cell carcinomas and adenocarcinomas of the oesophagus; they find genomic and molecular features that differentiate squamous and adenocarcinomas of the oesophagus, and strong similarities between oesophageal adenocarcinomas and the chromosomally unstable variant of gastric adenocarcinoma, suggesting that gastroesophageal adenocarcinoma is a single disease entity.

Jihun Kim
Reanne Bowlby
Jiashan Zhang
ResearchOpen Access04 Jan 2017
Nature

Volume: 541, P: 169-175
Comprehensive genomic characterization of head and neck squamous cell carcinomas

The Cancer Genome Atlas presents an integrative genome-wide analysis of genetic alterations in 279 head and neck squamous cell carcinomas (HNSCCs), which are classified by human papillomavirus (HPV) status; alterations in EGFR, FGFR, PIK3CA and cyclin-dependent kinases are shown to represent candidate targets for therapeutic intervention in most HNSCCs.

Michael S. Lawrence
Carrie Sougnez
Wendell G. Yarbrough
ResearchOpen Access28 Jan 2015
Nature

Volume: 517, P: 576-582
Author Correction: Dysregulated ribonucleoprotein granules promote cardiomyopathy in RBM20 gene-edited pigs

Jay W. Schneider
Saji Oommen
Janell K. Fox
Amendments and Corrections02 Jun 2021
Nature Medicine

Volume: 27, P: 1309
Suppressing quantum errors by scaling a surface code logical qubit

A study demonstrating increasing error suppression with larger surface code logical qubits, implemented on a superconducting quantum processor.

Rajeev Acharya
Igor Aleiner
Ningfeng Zhu
ResearchOpen Access22 Feb 2023
Nature

Volume: 614, P: 676-681
Exponential suppression of bit or phase errors with cyclic error correction

Repetition codes running many cycles of quantum error correction achieve exponential suppression of errors with increasing numbers of qubits.

Zijun Chen
Kevin J. Satzinger
Julian Kelly
ResearchOpen Access14 Jul 2021
Nature

Volume: 595, P: 383-387
Circulating tumour cells are a prognostic indicator in advanced high-grade serous ovarian cancer and are associated with platelets and immune cells following dissemination

Mark P. Ward
Faye Lewis
Sharon A. O’Toole
ResearchOpen Access10 Oct 2025
British Journal of Cancer

Volume: 134, P: 22-32
Combinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer

Targeting tyrosine kinase receptors that share the feedback inhibitor PTPN12 leads to broad spectrum therapeutic suppression of triple-negative breast cancer.

Amritha Nair
Hsiang-Ching Chung
Thomas F Westbrook
Research26 Mar 2018
Nature Medicine

Volume: 24, P: 505-511
Mitochondrial imaging in live or fixed tissues using a luminescent iridium complex

Alexandra Sorvina
Christie A. Bader
Douglas A. Brooks
ResearchOpen Access29 May 2018
Scientific Reports

Volume: 8, P: 1-8
Altered expression of vesicular trafficking machinery in prostate cancer affects lysosomal dynamics and provides insight into the underlying biology and disease progression

Bukuru D. Nturubika
Carlos M. Guardia
Ian R. D. Johnson
ResearchOpen Access31 Aug 2024
British Journal of Cancer

Volume: 131, P: 1263-1278
Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation

Patrick S Tarpey
F Lucy Raymond
Jozef Gécz
Research19 Aug 2007
Nature Genetics

Volume: 39, P: 1127-1133
TLR7 deficiency enhances inflammation in the URT but reduces LRT immunity following influenza A infection

Mark A. Miles
Sahan Jayawardena
Stavros Selemidis
ResearchOpen Access29 May 2025
Scientific Reports

Volume: 15, P: 1-16
Ex vivo expansion of circulating tumour cells (CTCs)

Bashir M. Mohamed
Mark P. Ward
John J. O’Leary
ResearchOpen Access06 Mar 2023
Scientific Reports

Volume: 13, P: 1-13
DNA repair deficiency biomarkers and the 70-gene ultra-high risk signature as predictors of veliparib/carboplatin response in the I-SPY 2 breast cancer trial

Denise M. Wolf
Christina Yau
Laura van ‘t Veer
ResearchOpen Access25 Aug 2017
npj Breast Cancer

Volume: 3, P: 1-9
Dynamic interplay between sortilin and syndecan-1 contributes to prostate cancer progression

Joanna Lazniewska
Ka Lok Li
Douglas A. Brooks
ResearchOpen Access18 Aug 2023
Scientific Reports

Volume: 13, P: 1-18
Author Correction: Perspectives on ENCODE

Federi Bronwen co Abascal
Reyes Acosta
Richard M. Myers
Amendments and CorrectionsOpen Access26 Apr 2022
Nature

Volume: 605, P: E4
Perspectives on ENCODE

The authors summarize the history of the ENCODE Project, the achievements of ENCODE 1 and ENCODE 2, and how the new data generated and analysed in ENCODE 3 complement the previous phases.

Federico Abascal
Reyes Acosta
Richard M. Myers
Reviews29 Jul 2020
Nature

Volume: 583, P: 693-698
Author Correction: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Amendments and Corrections21 Jul 2022
Nature

Volume: 608, P: E24
Author Correction: SARS-CoV-2 evolution during treatment of chronic infection

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Amendments and Corrections21 Jul 2022
Nature

Volume: 608, P: E23
Author Correction: Expanded encyclopaedias of DNA elements in the human and mouse genomes

Federico Abascal
Reyes Acosta
Zhiping Weng
Amendments and CorrectionsOpen Access26 Apr 2022
Nature

Volume: 605, P: E3
Publisher Correction: Genomic reconstruction of the SARS CoV-2 epidemic in England

Harald S. Vöhringer
Theo Sanderson
Moritz Gerstung
Amendments and CorrectionsOpen Access07 Jun 2022
Nature

Volume: 606, P: E18
Intranasal and epicutaneous administration of Toll-like receptor 7 (TLR7) agonists provides protection against influenza A virus-induced morbidity in mice

Eunice E. To
Jonathan Erlich
Stavros Selemidis
ResearchOpen Access20 Feb 2019
Scientific Reports

Volume: 9, P: 1-15
Physiological resistance alters behavioral response of Tetranychus urticae to acaricides

Adekunle W. Adesanya
Michael J. Beauchamp
Doug B. Walsh
ResearchOpen Access17 Dec 2019
Scientific Reports

Volume: 9, P: 1-12
The Cancer Genome Atlas Pan-Cancer analysis project

Current clinical practice is organized according to tissue or organ of origin of tumors. Now, The Cancer Genome Atlas (TCGA) Research Network has started to identify genomic and other molecular commonalities among a dozen different types of cancer. Emerging similarities and contrasts will form the basis for targeted therapies of the future and for repurposing existing therapies by molecular rather than histological similarities of the diseases.

Kyle Chang
Chad J Creighton
Joshua M Stuart
Comments & OpinionOpen Access26 Sept 2013
Nature Genetics

Volume: 45, P: 1113-1120
Paclitaxel sensitivity in relation to ABCB1 expression, efflux and single nucleotide polymorphisms in ovarian cancer

Bo Gao
Amanda Russell
Anna deFazio
ResearchOpen Access09 May 2014
Scientific Reports

Volume: 4, P: 1-9

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