Nature Search

Partial restoration of mitochondrial dysfunction by AAV-Ant1 protects from dilated cardiomyopathy in Ant1^-/- plus mtDNA mutant mice

Patients with primary mitochondrial disease manifesting cardiomyopathy are twice as likely to die compared to those without cardiomyopathy. Here, the authors show that a modest increase in cardiac mitochondrial energetics via gene therapy can significantly improve cardiac function and is effective in treating mitochondrial cardiomyopathy.

Alessia Angelin
Kierstin Keller
Douglas C. Wallace
ResearchOpen Access15 Dec 2025
Nature Communications

Volume: 17, P: 1-14
Maternally transmitted diabetes and deafness associated with a 10.4 kb mitochondrial DNA deletion

Scott W. Ballinger
John M. Shoffner
Douglas C. Wallace
Research01 Apr 1992
Nature Genetics

Volume: 1, P: 11-15
A mouse model for mitochondrial myopathy and cardiomyopathy resulting from a deficiency in the heart/muscle isoform of the adenine nucleotide translocator

Brett H. Graham
Katrina G. Waymire
Douglas C. Wallace
Research01 Jul 1997
Nature Genetics

Volume: 16, P: 226-234
Mitochondrial DNA Mutations Associated with Neuromuscular Diseases: Analysis and Diagnosis Using the Polymerase Chain Reaction

Douglas C Wallace
Marie T Lott
John M Shoffner
Research01 Nov 1990
Pediatric Research

Volume: 28, P: 525-528
Conformational mutations in human mitochondrial DNA

Gurparkash Singh
Nicolas Neckelmann
Douglas C. Wallace
Research17 Sept 1987
Nature

Volume: 329, P: 270-272
Respiration defects limit serine synthesis required for lung cancer growth and survival

The role of pathogenic mitochondrial DNA (mtDNA) mutation in cancer remains to be studied. Here the authors show that high mtDNA mutation burden in lung cancer models leads to increased glycolysis but limited de novo serine synthesis, rendering sensitivity to dietary serine and glycine deprivation.

Eduardo Cararo Lopes
Fuqian Shi
Eileen White
ResearchOpen Access15 Aug 2025
Nature Communications

Volume: 16, P: 1-17
A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase

Simon Melov
Julie A. Schneider
Douglas C. Wallace
Research01 Feb 1998
Nature Genetics

Volume: 18, P: 159-163
Three-dimensional structure of the lipovitellin–phosvitin complex from amphibian oocytes

Douglas H. Ohlendorf
Richard F. Wrenn
Leonard J. Banaszak
Research02 Mar 1978
Nature

Volume: 272, P: 28-32
Mitochondrial Diseases in Men and Mice

Douglas C Wallace
Research01 Jan 2000
Genetics in Medicine

Volume: 2, P: 6
Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age

Marisol Corral-Debrinski
Terzah Horton
Douglas C. Wallace
Research01 Dec 1992
Nature Genetics

Volume: 2, P: 324-329
Prevention of breast tumour development in vivo by downregulation of the p185^neureceptor

Makoto Katsumata
Tadao Okudaira
Mark I. Greene
Research01 Jul 1995
Nature Medicine

Volume: 1, P: 644-648
Somatic deletion of the neurofibromatosis type 1 gene in a neurofibrosarcoma supports a tumour suppressor gene hypothesis

Eric Legius
Douglas A. Marchuk
Thomas W. Glover
Research01 Feb 1993
Nature Genetics

Volume: 3, P: 122-126
Familial male breast cancer is not linked to the BRCA1 locus on chromosome 17q

Michael R. Stratton
Deborah Ford
David E. Goldgar
Research01 May 1994
Nature Genetics

Volume: 7, P: 103-107
Cellular origin and role of mink cell focus-forming viruses in murine thymic lymphomas

Sisir K. Chattopadhyay
Miles W. Cloyd
Douglas R. Lowy
Research07 Jan 1982
Nature

Volume: 295, P: 25-31
The macromolecular states of solvent-swollen and dry coal

Douglas Brenner
Research22 Dec 1983
Nature

Volume: 306, P: 772-773
Polygenic and developmental profiles of autism differ by age at diagnosis

A study of several longitudinal birth cohorts and cross-sectional cohorts finds only moderate overlap in genetic variants between autism that is diagnosed earlier and that diagnosed later, so they may represent aetiologically different conditions.

Xinhe Zhang
Jakob Grove
Varun Warrier
ResearchOpen Access01 Oct 2025
Nature

Volume: 646, P: 1146-1155
Dr. Siemens's Gas-Grate

R. DOUGLAS HALE
Research16 Dec 1880
Nature

Volume: 23, P: 145
Hepatocyte mitochondrial NAD⁺ content is limiting for liver regeneration

Modulating mitochondrial NAD⁺ levels by changing the expression of the mitochondrial NAD⁺ transporter, SLC25A51, Mukherjee et al. demonstrate that mitochondrial, rather than cytosolic or nuclear, NAD⁺ levels are a key determinant of the rate of liver regeneration.

Sarmistha Mukherjee
Ricardo A. Velázquez Aponte
Joseph A. Baur
ResearchOpen Access20 Nov 2025
Nature Metabolism

Volume: 7, P: 2424-2437
Average Height of Barometer in London

E. DOUGLAS ARCHIBALD
Research13 Jan 1881
Nature

Volume: 23, P: 243
Bedrock incision, rock uplift and threshold hillslopes in the northwestern Himalayas

Douglas W. Burbank
John Leland
Christopher Duncan
Research08 Feb 1996
Nature

Volume: 379, P: 505-510
Respiratory viral infections awaken metastatic breast cancer cells in lungs

Mouse models show that respiratory infections from viruses such as influenza and SARS-CoV-2 can trigger metastasis of dormant breast cancer cells in the lungs, a finding supported by epidemiological data from two large human cohorts.

Shi B. Chia
Bryan J. Johnson
James DeGregori
ResearchOpen Access30 Jul 2025
Nature

Volume: 645, P: 496-506
Normal long bone growth and development in type X collagen-null mice

Rita Rosati
Gerald S. B. Horan
Richard R. Behringer
Research01 Oct 1994
Nature Genetics

Volume: 8, P: 129-135
Alteration in crossbridge kinetics caused by mutations in actin

Douglas R. Drummond
Michelle Peckham
David C. S. White
Research29 Nov 1990
Nature

Volume: 348, P: 440-442
Combined ketone body and glutamine supplementation restores aerobic energy production in AGC1-deficient neuronal progenitors

Simona Nicole Barile
Maria Chiara Magnifico
Francesco Massimo Lasorsa
ResearchOpen Access15 Dec 2025
Cell Death & Disease

Volume: 17, P: 1-17
H⁺ transport is an integral function of the mitochondrial ADP/ATP carrier

The mitochondrial ADP/ATP carrier mediates the proton leak in mitochondria from all tissues that lack UCP1, thereby linking coupled (ATP production) and uncoupled (thermogenesis) energy conversion.

Ambre M. Bertholet
Edward T. Chouchani
Yuriy Kirichok
Research24 Jul 2019
Nature

Volume: 571, P: 515-520
Viscous fingering of HCI through gastric mucin

K. Ramakrishnan Bhaskar
Peter Garik
J. Thomas LaMont
Research03 Dec 1992
Nature

Volume: 360, P: 458-461
A deep earthquake aftershock sequence and implications for the rupture mechanism of deep earthquakes

Douglas A. Wiens
Jeffrey J. McGuire
Saimon P. Helu
Research08 Dec 1994
Nature

Volume: 372, P: 540-543
Functional topographic mapping of the cortical ribbon in human vision with conventional MRI scanners

Walter Schneider
Douglas C. Noll
Jonathan D. Cohen
Research09 Sept 1993
Nature

Volume: 365, P: 150-153
Cytomegalovirus vaccine vector-induced effector memory CD4 + T cells protect cynomolgus macaques from lethal aerosolized heterologous avian influenza challenge

Influenza genetic diversity is a key challenge in the design of a universal influenza vaccine that protects against different strains of influenza virus. Here, Malouli and colleagues demonstrate use of a cytomegalovirus-based T cell vaccine that induces immunity and can protect macaques from lethal avian influenza challenge with heterologous strains of influenza and suggest protection is linked to the generation of lung-resident influenza-specific CD4⁺ T cells.

Daniel Malouli
Meenakshi Tiwary
Jonah B. Sacha
ResearchOpen Access19 Jul 2024
Nature Communications

Volume: 15, P: 1-12
Post-transcriptional methylation of mitochondrial-tRNA differentially contributes to mitochondrial pathology

Here the authors show that the m¹G9 post-transcriptional methylation differentially regulates the stability of the native and the MELAS variants of human mt-Leu(UAA) tRNA, contributing to mitochondrial pathology.

Sunita Maharjan
Howard Gamper
Ya-Ming Hou
ResearchOpen Access18 Oct 2024
Nature Communications

Volume: 15, P: 1-17
Datopotamab–deruxtecan in early-stage breast cancer: the sequential multiple assignment randomized I-SPY2.2 phase 2 trial

In the I-SPY2.2 trial, patients with high-risk stage 2/3 breast cancer received neoadjuvant datopotamab–deruxtecan, followed by sequential chemotherapy with or without targeted therapy, with the option of early surgical resection after each block of therapy. In a subgroup of patients, the sequential treatment strategy was superior to standard of care.

Katia Khoury
Jane L. Meisel
Laura J. Esserman
Research14 Sept 2024
Nature Medicine

Volume: 30, P: 3728-3736
Datopotamab–deruxtecan plus durvalumab in early-stage breast cancer: the sequential multiple assignment randomized I-SPY2.2 phase 2 trial

In the I-SPY2.2 trial, patients with high-risk stage 2/3 breast cancer received neoadjuvant datopotamab–deruxtecan plus durvalumab, followed by sequential chemotherapy with or without targeted therapy, with the option of early surgical resection after each block of therapy, showing that de-escalation of therapy is possible for several patient subgroups without compromising outcome and avoiding toxicity of standard chemotherapy.

Rebecca A. Shatsky
Meghna S. Trivedi
Laura J. Esserman
Research14 Sept 2024
Nature Medicine

Volume: 30, P: 3737-3747
Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

Yibing Li
Ting-Ting Huang
Charles J. Epstein
Research01 Dec 1995
Nature Genetics

Volume: 11, P: 376-381
Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

The goals, resources and design of the NHLBI Trans-Omics for Precision Medicine (TOPMed) programme are described, and analyses of rare variants detected in the first 53,831 samples provide insights into mutational processes and recent human evolutionary history.

Daniel Taliun
Daniel N. Harris
Gonçalo R. Abecasis
ResearchOpen Access10 Feb 2021
Nature

Volume: 590, P: 290-299
sChemNET: a deep learning framework for predicting small molecules targeting microRNA function

Here the authors developed and experimentally validated sChemNET, a deep learning framework to predict small molecules affecting microRNA function based on chemical structure and sequence data. sChemNET predicts bioactive small molecules on the basis of sparse chemical datasets.

Diego Galeano
Imrat
Afshin Beheshti
ResearchOpen Access23 Oct 2024
Nature Communications

Volume: 15, P: 1-16
IgD in Human Colostrum

Margaret A Keller
Douglas C Heiner
Diane M Reisinger
Research01 Jan 1985
Pediatric Research

Volume: 19, P: 122-126
Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility

Meta-analysis of 36,760 cases and 375,188 controls identifies 54 loci associated with susceptibility to cutaneous melanoma. Further analysis combining nevus count and hair color GWAS results provide insights into the genetic architecture of melanoma.

Maria Teresa Landi
D. Timothy Bishop
Matthew H. Law
Research27 Apr 2020
Nature Genetics

Volume: 52, P: 494-504
Anthropogenic organic aerosol in Europe produced mainly through second-generation oxidation

Second-generation oxidation boosts the production of anthropogenic organic aerosol, according to an analysis of urban haze in an experimental chamber.

Mao Xiao
Mingyi Wang
Imad El Haddad
ResearchOpen Access10 Mar 2025
Nature Geoscience

Volume: 18, P: 239-245
APOGEE 2: multi-layer machine-learning model for the interpretable prediction of mitochondrial missense variants

APOGEE 2 is a machine-learning tool for assessing the fragility of the mitochondrial genome, evaluating genetic variant pathogenicity and ultimately enhancing our understanding of the clinical heterogeneity of mitochondrial genetic diseases.

Salvatore Daniele Bianco
Luca Parca
Tommaso Mazza
ResearchOpen Access19 Aug 2023
Nature Communications

Volume: 14, P: 1-13
Mitochondrial diabetes revisited

Scott W. Ballinger
John M. Shoffner
Douglas C. Wallace
Correspondence01 Aug 1994
Nature Genetics

Volume: 7, P: 458-459
Endosomolytic polymersomes increase the activity of cyclic dinucleotide STING agonists to enhance cancer immunotherapy

Rationally designed polymer vesicles increase cytosolic delivery of cGAMP, activating the STING pathway and increasing the immunogenicity of the tumour microenvironment in in vivo murine models of melanoma and in human metastatic melanoma tissues.

Daniel Shae
Kyle W. Becker
John T. Wilson
Research21 Jan 2019
Nature Nanotechnology

Volume: 14, P: 269-278
Amalgamation of Some Alloys of Gold, Silver and Copper

DOUGLAS RENNIE HUDSON
News21 Feb 1948
Nature

Volume: 161, P: 288-289
Correction: Corrigendum: Landscape of the mitochondrial Hsp90 metabolome in tumours

Young Chan Chae
Alessia Angelin
Dario C. Altieri
Amendments and Corrections18 Jun 2015
Nature Communications

Volume: 6, P: 1
Immune resilience despite inflammatory stress promotes longevity and favorable health outcomes including resistance to infection

The response to infectious and inflammatory challenges differs among people but the reasons for this are poorly understood. Here the authors explore the impact of variables such as age, sex, and the capacity for controlling inflammation and maintaining immunocompetence, linking this capacity to favourable health outcomes and lifespan.

Sunil K. Ahuja
Muthu Saravanan Manoharan
Weijing He
ResearchOpen Access13 Jun 2023
Nature Communications

Volume: 14, P: 1-31
Distribution of Cardiac Output in Fetal and Neonatal Lambs with Acute Respiratory Acidosis

Adam A Rosenberg
Raymond C Koehler
M Douglas Jones Jr.
Research01 Aug 1984
Pediatric Research

Volume: 18, P: 731-735
Space radiation damage rescued by inhibition of key spaceflight associated miRNAs

In space radiation-exposed cells, targeting specific microRNAs with antagomirs can reduce cardiovascular damage and improve cellular function. Here the authors describe a reduction in inflammation and DNA double-strand break activity within these cells upon antagomir treatment.

J. Tyson McDonald
JangKeun Kim
Afshin Beheshti
ResearchOpen Access11 Jun 2024
Nature Communications

Volume: 15, P: 1-23
Changes in the solar constant and climatic effects

John A. Eddy
Ronald L. Gilliland
Douglas V. Hoyt
Reviews23 Dec 1982
Nature

Volume: 300, P: 689-693
Spatially resolved multiomics on the neuronal effects induced by spaceflight in mice

A spatial transcriptomics and single-cell multiomics study performed on mouse brain tissue. Here, authors show region-specific spaceflight-induced alterations in processes of neurogenesis, synaptogenesis and synaptic transmission.

Yuvarani Masarapu
Egle Cekanaviciute
Stefania Giacomello
ResearchOpen Access11 Jun 2024
Nature Communications

Volume: 15, P: 1-14
Solar constant

PETER FOUKAL
DOUGLAS HOYT
Correspondence02 Jun 1983
Nature

Volume: 303, P: 372
The ADP/ATP translocase drives mitophagy independent of nucleotide exchange

A CRISPR–Cas9 genetic screen shows that the adenine nucleotide translocator is required for mitophagy and that this role is independent of its nucleotide translocase activity.

Atsushi Hoshino
Wei-jia Wang
Zoltan Arany
Research16 Oct 2019
Nature

Volume: 575, P: 375-379

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