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Showing 1–3 of 3 results
Advanced filters: Author: Douglas S. Micalizzi Clear advanced filters

  • Circulating tumor cells (CTCs) are clinically useful for detecting and monitoring cancer, but they are rare in blood. Here, the authors use a highthroughput microfluidic device to massively enrich CTCs from leukapheresis products to uncover single cell molecular features in prostate and other cancers.

    • Avanish Mishra
    • Shih-Bo Huang
    • Mehmet Toner
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • During breast-cancer progression, tumour cells that arise in the milk duct spread elsewhere in the breast. The origin of these invasive tumour cells is now revealed by an analysis of spatially defined single cells.

    • Douglas S. Micalizzi
    • Shyamala Maheswaran
    News & Views
    Nature
    Volume: 554, P: 308-309

  • The mechanisms underlying the growth of breast cancer metastasis in the brain are unclear. Here, the authors use an intracranial injection mouse model and single-cell analysis of patient circulating tumour cells to demonstrate that increased hypoxic and HIF1A signalling promotes tumour growth in the brain.

    • Richard Y. Ebright
    • Marcus A. Zachariah
    • Shyamala Maheswaran
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13