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Showing 1–3 of 3 results
Advanced filters: Author: Douglas V. Faget Clear advanced filters

  • Chemotherapy induces bone loss that compromises skeletal health in cancer patients. Here, the authors show that chemotherapy-induced senescence in bone marrow adipo-lineage cells leads to bone loss and demonstrate that senolytic targeting of senescent cells preserves skeletal health during chemotherapy, providing a potential strategy to protect the skeleton in cancer therapy.

    • Ganesh Kumar Raut
    • Taylor Malachowski
    • Sheila A. Stewart
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-20

  • This Review discusses the diverse effects of senescence and the senescence-associated secretory phenotype (SASP) on tumour growth, focusing on the functional and sometimes opposing outputs of the SASP in stromal cells and incipient tumour cells.

    • Douglas V. Faget
    • Qihao Ren
    • Sheila A. Stewart
    Reviews
    Nature Reviews Cancer
    Volume: 19, P: 439-453

  • Fibroblasts become activated during wound repair and rapidly return to a ‘resting’ state, and are thus critical for normal tissue homeostasis and tumour development. A new study now reveals an important pro-tumorigenic role for the stress response in cancer-associated fibroblasts that may offer a new opportunity to limit tumour progression.

    • Douglas V. Faget
    • Sheila A. Stewart
    News & Views
    Nature Cell Biology
    Volume: 24, P: 812-814