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Autophagy impairment in liver CD11c⁺ cells promotes non-alcoholic fatty liver disease through production of IL-23

The function of autophagy and how this affects non-alcoholic fatty liver disease is not fully known. Here the authors show that in mice with a targeted disruption of the autophagy pathway in CD11c⁺ cells, development of NAFLD is accelerated involving IL-23 and blocking of IL-23 reduces disease.

Lauriane Galle-Treger
Doumet Georges Helou
Omid Akbari
ResearchOpen Access17 Mar 2022
Nature Communications

Volume: 13, P: 1-16
Orai inhibition modulates pulmonary ILC2 metabolism and alleviates airway hyperreactivity in murine and humanized models

The regulation and intracellular transport of Ca²⁺ in immune cells involves Ca²⁺ release-activated Ca²⁺ (CRAC) channels. Here the authors show targeting CRAC components Orai1 and Orai2 modulates pulmonary ILC2 cells altering their metabolism, function and is linked to alleviation of immunopathology in a murine model of allergic airway disease.

Emily Howard
Benjamin P. Hurrell
Omid Akbari
ResearchOpen Access26 Sept 2023
Nature Communications

Volume: 14, P: 1-13
PD-L2 controls peripherally induced regulatory T cells by maintaining metabolic activity and Foxp3 stability

Regulatory T (Treg) cells have been implicated in the induction of airway tolerance and amelioration of respiratory duct inflammation. Here the authors show, using PD-L2 deficient mice, that the immune suppression signal from PD-L2 is important for modulating Treg cell metabolism and function for proper induction of respiratory tolerance in mice.

Benjamin P. Hurrell
Doumet Georges Helou
Omid Akbari
ResearchOpen Access31 Aug 2022
Nature Communications

Volume: 13, P: 1-14
CD200–CD200R immune checkpoint engagement regulates ILC2 effector function and ameliorates lung inflammation in asthma

The role of the CD200–CD200R axis in regulating pulmonary inflammation is not completely understood. Here the authors show CD200R is expressed on type 2 innate lymphoid cells (ILC2s), and its engagement by CD200 ameliorates airway hyperreactivity and allergic asthma via inhibition of NF-κB signaling.

Pedram Shafiei-Jahani
Doumet Georges Helou
Omid Akbari
ResearchOpen Access05 May 2021
Nature Communications

Volume: 12, P: 1-15
DR3 stimulation of adipose resident ILC2s ameliorates type 2 diabetes mellitus

Group 2 innate lymphoid cells (ILC2s) are immune cells present in adipose tissue that contribute to metabolic homeostasis. Here the authors show that Death Receptor 3 (DR3) engagement on ILC2s ameliorates glucose tolerance, protects against insulin-resistance onset and reverses established insulin-resistance.

Pedram Shafiei-Jahani
Benjamin P. Hurrell
Omid Akbari
ResearchOpen Access18 Sept 2020
Nature Communications

Volume: 11, P: 1-15
PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity

PD-1 is a checkpoint inhibitory immune receptor that restrains proliferation and effector functions of a variety of cells, including ILC2s. Here the authors present a human PD-1 agonist that limits ILC2-dependent allergic airway disease in humanized mice and provide evidence that PD-1 signaling alters ILC2 function by modulation of cell metabolism.

Doumet Georges Helou
Pedram Shafiei-Jahani
Omid Akbari
ResearchOpen Access10 Aug 2020
Nature Communications

Volume: 11, P: 1-15
CD52-targeted depletion by Alemtuzumab ameliorates allergic airway hyperreactivity and lung inflammation

Pedram Shafiei-Jahani
Doumet Georges Helou
Omid Akbari
Research17 Mar 2021
Mucosal Immunology

Volume: 14, P: 899-911

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Autophagy impairment in liver CD11c+ cells promotes non-alcoholic fatty liver disease through production of IL-23

Orai inhibition modulates pulmonary ILC2 metabolism and alleviates airway hyperreactivity in murine and humanized models

PD-L2 controls peripherally induced regulatory T cells by maintaining metabolic activity and Foxp3 stability

CD200–CD200R immune checkpoint engagement regulates ILC2 effector function and ameliorates lung inflammation in asthma

DR3 stimulation of adipose resident ILC2s ameliorates type 2 diabetes mellitus

PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity

CD52-targeted depletion by Alemtuzumab ameliorates allergic airway hyperreactivity and lung inflammation

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Autophagy impairment in liver CD11c⁺ cells promotes non-alcoholic fatty liver disease through production of IL-23