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Showing 1–3 of 3 results
Advanced filters: Author: Draven A. Rane Clear advanced filters

  • A major challenge in coronavirus vaccination and treatment is to counteract rapid viral evolution and mutations. Here the authors show that CRISPR-Cas13d can be used as a broad-spectrum antiviral to inhibit human coronaviruses, including new SARS-CoV-2 variants, combined with small molecule drugs for an enhanced antiviral effect in human primary cells.

    • Leiping Zeng
    • Yanxia Liu
    • Lei S. Qi
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • Through structure-guided protein engineering, Guo et al. developed a Lachnospiraceae bacterium Cas12a variant with enhanced editing efficiency and applied the enzyme-dead version of this variant for multiplex gene activation in the mouse retina.

    • Lucie Y. Guo
    • Jing Bian
    • Lei S. Qi
    Research
    Nature Cell Biology
    Volume: 24, P: 590-600