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Showing 1–4 of 4 results
Advanced filters: Author: Dritan Agalliu Clear advanced filters

  • Defective neoangiogenesis and blood–brain barrier leakiness are pathological hallmarks of neuroinflammation. Here the authors show that vascular endothelial growth factor A (VEGF-A) promotes venous endothelial cell proliferation, resulting in the formation of leaky vessels around demyelinating lesions in multiple sclerosis and experimental autoimmune encephalomyelitis.

    • Sanjid Shahriar
    • Saptarshi Biswas
    • Dritan Agalliu
    Research
    Nature Neuroscience
    Volume: 27, P: 1904-1917

  • Focused ultrasound can transiently open the blood–brain barrier for drug delivery, but the cellular responses of brain endothelial cells remain unclear. Rebecca Lynn Noel and colleagues report how low or high ultrasound pressures differently reorganize tight junction proteins, defining conditions for safe and reversible barrier opening.

    • Rebecca Lynn Noel
    • Tara Kugelman
    • Elisa E. Konofagou
    ResearchOpen Access
    Communications Engineering
    Volume: 5, P: 1-16

  • Hereditary hypotrichosis simplex is a rare form of hereditary hair loss in humans, where the hair follicle is miniaturized. Now, the gene involved has been identified, using genetic linkage analysis in three affected families. The gene, APCDD1, is expressed in human hair follicles. It encodes a previously unknown membrane-bound glycoprotein that inhibits signalling through the Wnt protein and functions upstream of β-catenin.

    • Yutaka Shimomura
    • Dritan Agalliu
    • Angela M. Christiano
    Research
    Nature
    Volume: 464, P: 1043-1047

  • The authors show that Netrin-1-Unc5B signaling controls blood-brain barrier integrity by maintaining Wnt/b-catenin signaling and that delivery of antibodies blocking Netrin-1 binding to Unc5B causes transient and size-selective BBB breakdown.

    • Kevin Boyé
    • Luiz Henrique Geraldo
    • Anne Eichmann
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15