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Showing 1–2 of 2 results
Advanced filters: Author: Duncan Browman Clear advanced filters

  • The success of HER2-targeted cancer therapy is limited by treatment resistance. Here, the authors engineer an anti-HER2 biparatopic antibody with multiple mechanisms of action including induction of HER2 clustering to trigger complement dependent cytotoxicity, signal inhibition, antibody dependent cellular cytotoxicity and phagocytosis.

    • Nina E. Weisser
    • Mario Sanches
    • Surjit Dixit
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-22

  • Tunnelling nanotubes provide a means of intercellular communication. They are now shown to facilitate spreading of prions between neuronal cells, as well as their propagation from dentritic cells to primary neurons.

    • Karine Gousset
    • Edwin Schiff
    • Chiara Zurzolo
    Research
    Nature Cell Biology
    Volume: 11, P: 328-336