Nature Search

GO faster ChEBI with Reasonable Biochemistry

Duncan Hull
ResearchOpen Access25 Sept 2008
Nature Precedings

P: 1
Data integration in myGrid with Taverna

Duncan Hull
ResearchOpen Access03 Jul 2007
Nature Precedings

P: 1
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Decoupling body shape and mass distribution in birds and their dinosaurian ancestors

Here, the authors track the evolution of mass distribution through bird evolution challenging suggested coupling between body shape and centre-of-mass position, and instead showing that crouched bipedalism evolved after powered flight.

Sophie Macaulay
Tatjana Hoehfurtner
Karl T. Bates
ResearchOpen Access22 Mar 2023
Nature Communications

Volume: 14, P: 1-12
Body size, shape and ecology in tetrapods

Here, the authors examine how body size, shape, and segment proportions correspond to ecology in models of 410 tetrapods. They find variable allometric relationships, differential scaling in small and large animals, and body proportions as a potential niche occupation mechanism.

Alice E. Maher
Gustavo Burin
Karl T. Bates
ResearchOpen Access27 Jul 2022
Nature Communications

Volume: 13, P: 1-16
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Whatever floats your boat

Shipping is one of the most fuel-efficient ways to move freight, but the industry still produces significant greenhouse-gas emissions, including more than a quarter of the world's nitrogen oxides emissions. And it also produces more sulphur dioxide emissions than all land transportation combined. In the latest of our Future Transport series, Duncan Graham-Rowe looks at the new wave in shipping.

Duncan Graham-Rowe
News20 Aug 2008
Nature

Volume: 454, P: 924-925
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
GO faster ChEBI with Reasonable Biochemistry

Duncan Hull
MultimediaOpen Access24 Oct 2008
Nature Precedings

P: 1
Tumour tropism and anti-cancer efficacy of polymer-based doxorubicin prodrugs in the treatment of subcutaneous murine B16F10 melanoma

LW Seymour
K Ulbrich
R Duncan
Research01 Oct 1994
British Journal of Cancer

Volume: 70, P: 636-641
Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity

Walmsley and colleagues report that systemic hypoxia induces persistent loss of histone H3K4me3 marks and epigenetic reprogramming in neutrophil progenitors, resulting in long-term impairment of subsequent neutrophil effector functions.

Manuel A. Sanchez-Garcia
Pranvera Sadiku
Sarah R. Walmsley
ResearchOpen Access28 Oct 2025
Nature Immunology

Volume: 26, P: 1903-1915
Author Correction: Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity

Manuel A. Sanchez-Garcia
Pranvera Sadiku
Sarah R. Walmsley
Amendments and CorrectionsOpen Access01 Dec 2025
Nature Immunology

Volume: 27, P: 377
An invasive pathogen drives directional niche contractions in amphibians

Analysing the extent of occurrence and niche hypervolumes of 55 species of frogs in eastern Australia, the authors show that species impacted by the introduction of the pathogenic amphibian chytrid fungus underwent niche contractions, and that these were in a direction that could inhibit chytrid fungus and/or promote host demographic resilience.

Ben C. Scheele
Geoffrey W. Heard
Jarrod Sopniewski
Research07 Aug 2023
Nature Ecology & Evolution

Volume: 7, P: 1682-1692
Spreading ridge migration enabled by plume-ridge de-anchoring

When mantle plumes are coupled to spreading ridges, they can act as an anchor and impede spreading ridge migration but if the plume weakens, it can de-anchor from the ridge and facilitate rapid ridge migration.

Ben Mather
Maria Seton
Robert Duncan
ResearchOpen Access16 Oct 2024
Nature Communications

Volume: 15, P: 1-11
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
N-(2-Hydroxypropyl)methacrylamide copolymers targeted to the hepatocyte galactose-receptor: pharmacokinetics in DBA₂ mice

LW Seymour
K Ulbrich
R Duncan
Research01 Dec 1991
British Journal of Cancer

Volume: 63, P: 859-866
PDEPT: polymer-directed enzyme prodrug therapy

R Satchi
T A Connors
R Duncan
ResearchOpen Access02 Oct 2001
British Journal of Cancer

Volume: 85, P: 1070-1076
Mind and Matter

WM. S. DUNCAN
Research01 Nov 1876
Nature

Volume: 15, P: 78-79
Breaking up is hard to do

Single-hulled ships are being rushed to the scrapyard in the wake of oil spills such as that of the Prestige. But will breaking them up cause environmental havoc too? Duncan Graham-Rowe finds out.

Duncan Graham-Rowe
News24 Jun 2004
Nature

Volume: 429, P: 800-802
Research and Development

DUNCAN BURN
Correspondence24 Sept 1971
Nature

Volume: 233, P: 291-292
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) is an anti-inflammatory drug proposed as a treatment for COVID19. Here the results are reported from a randomised trial testing DMF treatment in 713 patients hospitalised with COVID-19. DMF was not associated with any improvement in day 5 outcomes.

Peter Sandercock
Janet Darbyshire
Martin J. Landray
ResearchOpen Access31 Jan 2024
Nature Communications

Volume: 15, P: 1-13
Genetic mechanisms of critical illness in COVID-19

A genome-wide association study of critically ill patients with COVID-19 identifies genetic signals that relate to important host antiviral defence mechanisms and mediators of inflammatory organ damage that may be targeted by repurposing drug treatments.

Erola Pairo-Castineira
Sara Clohisey
J. Kenneth Baillie
Research11 Dec 2020
Nature

Volume: 591, P: 92-98
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Felicity Liew
Claudia Efstathiou
J. Eunice Zhang
ResearchOpen Access08 Apr 2024
Nature Immunology

Volume: 25, P: 607-621
Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

Fine-scale geospatial mapping of overweight and wasting (two components of the double burden of malnutrition) in 105 LMICs shows that overweight has increased from 5.2% in 2000 to 6.0% in children under 5 in 2017. Although overall wasting decreased over the same period, most countries are not on track to meet the World Health Organization’s Global Nutrition Target of <5% in over half of LMICs by 2025.

Damaris K. Kinyoki
Jennifer M. Ross
Simon I. Hay
ResearchOpen Access20 Apr 2020
Nature Medicine

Volume: 26, P: 750-759
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Optimality guarantees for crystal structure prediction

An algorithm has been developed that can provably predict the lowest energy structure of crystalline materials using a combination of combinatorial optimization and integer programming.

Vladimir V. Gusev
Duncan Adamson
Matthew J. Rosseinsky
Research05 Jul 2023
Nature

Volume: 619, P: 68-72
ChEBI – an Open-access Chemistry Resource for the Life Sciences:*Facilities for On-line Submission and Curation

Duncan Hull
Zara Josephs
Kenneth Haug
MultimediaOpen Access22 Oct 2010
Nature Precedings

P: 1
Effect of Reconstituted Pulmonary Surfactant Containing the 6000-Dalton Hydrophobic Protein on Lung Compliance of Prematurely Delivered Rabbit Fetuses

Shou-Haw Yu
Duncan Wallace
Fred Possmayer
Research01 Jan 1988
Pediatric Research

Volume: 23, P: 23-30
Sensors take the strain

A growing number of enterprises around the world are now commercializing fibre Bragg grating sensors for sensing everything from temperature and pressure to vibration and strain. Duncan Graham-Rowe reports.

Duncan Graham-Rowe
Comments & Opinion01 Jun 2007
Nature Photonics

Volume: 1, P: 307-309
The basic leucine zipper transcription factor E4BP4 is essential for natural killer cell development

Little is known about the transcription factors that facilitate NK cell differentiation. Brady and colleagues find that the basic leucine zipper transcription factor E4bp4 is essential for NK cell development in mice.

Duncan M Gascoyne
Elaine Long
Hugh J M Brady
Research13 Sept 2009
Nature Immunology

Volume: 10, P: 1118-1124
Testing the form-function paradigm: body shape correlates with kinematics but not energetics in selectively-bred birds

Duck breeds selectively bred for disparate body shapes are found to walk with different limb kinematics but incur similar energetic costs. This is attributed to the interplay of dynamic kinematic and modular anatomical processes.

Samuel R. R. Cross
Andres C. Marmol-Guijarro
Jonathan R. Codd
ResearchOpen Access24 Jul 2024
Communications Biology

Volume: 7, P: 1-14
Correlates of protection against symptomatic and asymptomatic SARS-CoV-2 infection

Defined levels of SARS-CoV-2-specific binding and neutralizing antibodies elicited by the COVID-19 vaccine ChAdOx1 nCoV-19 are identified as correlates of protection against symptomatic infection.

Shuo Feng
Daniel J. Phillips
Christopher J. Williams
ResearchOpen Access29 Sept 2021
Nature Medicine

Volume: 27, P: 2032-2040
Capturing the cloud of diversity reveals complexity and heterogeneity of MRSA carriage, infection and transmission

Populations of bacterial pathogens can be diverse within colonized individuals. Here, the authors sequence the genomes of methicillin-resistant Staphylococcus aureusisolated from staff and animal patients at a veterinary hospital and show considerable within-host diversity that can rise and fall over time.

Gavin K. Paterson
Ewan M. Harrison
Mark A. Holmes
ResearchOpen Access27 Mar 2015
Nature Communications

Volume: 6, P: 1-10
SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

The Omicron variant evades vaccine-induced neutralization but also fails to form syncytia, shows reduced replication in human lung cells and preferentially uses a TMPRSS2-independent cell entry pathway, which may contribute to enhanced replication in cells of the upper airway. Altered fusion and cell entry characteristics are linked to distinct regions of the Omicron spike protein.

Brian J. Willett
Joe Grove
Emma C. Thomson
ResearchOpen Access07 Jul 2022
Nature Microbiology

Volume: 7, P: 1161-1179
Human leukocyte antigen alleles associate with COVID-19 vaccine immunogenicity and risk of breakthrough infection

Variation in antibody levels elicited by the COVID-19 vaccine ChAdOx1 nCov-19 is linked to specific major histocompatibility complex class II alleles, providing insight into the breadth of immune response among vaccinated individuals.

Alexander J. Mentzer
Daniel O’Connor
Julian C. Knight
ResearchOpen Access13 Oct 2022
Nature Medicine

Volume: 29, P: 147-157
Genomic reconstruction of the SARS-CoV-2 epidemic in England

A study of the evolution of the SARS-CoV-2 virus in England between September 2020 and June 2021 finds that interventions capable of containing previous variants were insufficient to stop the more transmissible Alpha and Delta variants.

Harald S. Vöhringer
Theo Sanderson
Moritz Gerstung
ResearchOpen Access14 Oct 2021
Nature

Volume: 600, P: 506-511
SARS-CoV-2-specific immune responses and clinical outcomes after COVID-19 vaccination in patients with immune-suppressive disease

Serological analysis and infection outcomes of participants in the multi-center, prospectively enrolled OCTAVE cohort, comprising 2,686 participants with immune-suppressive diseases who recieved two COVID-19 vaccines, reveals specific clinical phenotypes that might benefit from specific COVID-19 therapeutic strategies.

Eleanor Barnes
Carl S. Goodyear
Deborah Richardson
ResearchOpen Access06 Jul 2023
Nature Medicine

Volume: 29, P: 1760-1774
A community-driven global reconstruction of human metabolism

The metabolic modeling community has curated information from five models to create the most comprehensive model of human metabolism to date.

Ines Thiele
Neil Swainston
Bernhard Ø Palsson
Research03 Mar 2013
Nature Biotechnology

Volume: 31, P: 419-425
Author Correction: Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

Damaris K. Kinyoki
Jennifer M. Ross
Simon I. Hay
Amendments and CorrectionsOpen Access02 Jul 2020
Nature Medicine

Volume: 26, P: 1308
Variants in CFAP410 cause a range of retinal and skeletal phenotypes

Ryan E. Schmidt
Amy E. Pohodich
Mark E. Pennesi
ResearchOpen Access17 Apr 2025
npj Genomic Medicine

Volume: 10, P: 1-11
COVID-19 due to the B.1.617.2 (Delta) variant compared to B.1.1.7 (Alpha) variant of SARS-CoV-2: a prospective observational cohort study

Kerstin Kläser
Erika Molteni
Emma L. Duncan
ResearchOpen Access28 Jun 2022
Scientific Reports

Volume: 12, P: 1-17
Combined analysis of IGHV mutations, telomere length and CD49d identifies long-term progression-free survivors in TP53 wild-type CLL treated with FCR-based therapies

Andrea G. S. Pepper
Antonella Zucchetto
Chris Pepper
ResearchOpen Access19 Jun 2021
Leukemia

Volume: 36, P: 271-274
Altered Expression of Angiopoietins During Blood-Brain Barrier Breakdown and Angiogenesis

Nima Nourhaghighi
Krystyna Teichert-Kuliszewska
Sukriti Nag
Research01 Aug 2003
Laboratory Investigation

Volume: 83, P: 1211-1222
Effective communication and ethical consent in decisions related to ICDs

This Review outlines the main ethical and legal issues surrounding informed consent for the insertion, removal, and deactivation of implantable cardioverter-defibrillators (ICDs). The authors also provide an overview of current guidelines for communication with and involvement of patients and next of kin throughout the decision-making process.

Alexander M. Clark
Tiny Jaarsma
David R. Thompson
Reviews26 Jul 2011
Nature Reviews Cardiology

Volume: 8, P: 694-705
Publisher Correction: Genomic reconstruction of the SARS CoV-2 epidemic in England

Harald S. Vöhringer
Theo Sanderson
Moritz Gerstung
Amendments and CorrectionsOpen Access07 Jun 2022
Nature

Volume: 606, P: E18
Healthy eating and lifestyle in pregnancy (HELP): a cluster randomised trial to evaluate the effectiveness of a weight management intervention for pregnant women with obesity on weight at 12 months postpartum

Sharon A. Simpson
Elinor Coulman
Rebecca Playle
ResearchOpen Access21 May 2021
International Journal of Obesity

Volume: 45, P: 1728-1739
Correction to: Healthy eating and lifestyle in pregnancy (HELP): a cluster randomised trial to evaluate the effectiveness of a weight management intervention for pregnant women with obesity on weight at 12 months postpartum

Sharon A. Simpson
Elinor Coulman
Rebecca Playle
Amendments and CorrectionsOpen Access18 Oct 2021
International Journal of Obesity

Volume: 46, P: 242
Publisher Correction: SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

Brian J. Willett
Joe Grove
Emma C. Thomson
Amendments and CorrectionsOpen Access16 Sept 2022
Nature Microbiology

Volume: 7, P: 1709
The cannabinoid Δ⁹-tetrahydrocannabivarin (THCV) ameliorates insulin sensitivity in two mouse models of obesity

E T Wargent
M S Zaibi
M A Cawthorne
ResearchOpen Access27 May 2013
Nutrition & Diabetes

Volume: 3, P: e68
Humoral immune responses to COVID-19 vaccination in people living with HIV receiving suppressive antiretroviral therapy

Zabrina L. Brumme
Francis Mwimanzi
Mark A. Brockman
ResearchOpen Access28 Feb 2022
npj Vaccines

Volume: 7, P: 1-12

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