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YAP induces an oncogenic transcriptional program through TET1-mediated epigenetic remodeling in liver growth and tumorigenesis

YAP upregulates TET1, which physically interacts with TEAD1/4 to demethylate DNA at YAP target genes in the liver. Loss of TET1 reverses YAP-induced chromatin and transcriptional changes and suppresses YAP-induced hepatomegaly and tumorigenesis.

Bo-Kuan Wu
Szu-Chieh Mei
Duojia Pan
Research14 Jul 2022
Nature Genetics

Volume: 54, P: 1202-1213
Innate immune and proinflammatory signals activate the Hippo pathway via a Tak1-STRIPAK-Tao axis

The evolutionally conserved Hippo pathway regulates essential developmental, homeostatic and regenerative processes, and is involved in the host defense against pathogens. Here authors show that in Drosophila Melanogaster and mammalian cells, innate immune stimuli activate Hippo via a pathway emanating from the Tak1 kinase and cascading down to Hippo via STRIPAK-Tao-Hpo signaling.

Yinan Yang
Huijing Zhou
Bo Liu
ResearchOpen Access02 Jan 2024
Nature Communications

Volume: 15, P: 1-17
YAP/TAZ drives cell proliferation and tumour growth via a polyamine–eIF5A hypusination–LSD1 axis

Li et al. show that YAP/TAZ directly promotes polyamine biosynthesis and activates eIF5A activity to upregulate LSD1 expression, thereby suppressing various genes including tumour suppressors to enhance tumour growth.

Hongde Li
Bo-Kuan Wu
Duojia Pan
Research17 Feb 2022
Nature Cell Biology

Volume: 24, P: 373-383
Spatiotemporal coordination of actin regulators generates invasive protrusions in cell–cell fusion

Lu et al. reveal the spatiotemporal coordination between two nucleation-promoting factors, WAVE and N-WASP, and two actin-bundling proteins, dynamin and WIP, in generating invasive protrusions at the mammalian myoblast fusogenic synapse.

Yue Lu
Tezin Walji
Elizabeth H. Chen
Research01 Nov 2024
Nature Cell Biology

Volume: 26, P: 1860-1877
Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

Yong Zhang
Xinsheng Gao
Duojia Pan
Research27 May 2003
Nature Cell Biology

Volume: 5, P: 578-581
Tsc tumour suppressor proteins antagonize amino-acid–TOR signalling

Xinsheng Gao
Yong Zhang
Duojia Pan
Research12 Aug 2002
Nature Cell Biology

Volume: 4, P: 699-704
A functional interaction between Hippo-YAP signalling and FoxO1 mediates the oxidative stress response

YAP is the terminal effector of the Hippo signalling pathway that regulates cell growth and survival. Shao et al.show that Hippo signalling also stimulates oxidative stress responses in cardiomyocytes, revealing YAP as a regulator of FoxO1-dependent antioxidant gene expression.

Dan Shao
Peiyong Zhai
Junichi Sadoshima
Research14 Feb 2014
Nature Communications

Volume: 5, P: 1-10
Control of stem cell renewal and fate by YAP and TAZ

YAP and TAZ are transcription coactivators with key roles in development and regeneration as well as in cancer. Many of these roles are executed by YAP/TAZ activation in stem cells. This Review discusses how YAP/TAZ regulate stem cell biology, and considers potential applications of modulating YAP/TAZ in regenerative medicine and cancer therapy.

Jordan H. Driskill
Duojia Pan
Reviews25 Aug 2023
Nature Reviews Molecular Cell Biology

Volume: 24, P: 895-911
Autopalmitoylation of TEAD proteins regulates transcriptional output of the Hippo pathway

Biochemical assays using activity-based chemical probes revealed that the Hippo pathway transcription factor TEAD undergoes autopalmitoylation to ensure binding to YAP/TAZ and promote muscle differentiation and tissue growth.

PuiYee Chan
Xiao Han
Xu Wu
Research22 Feb 2016
Nature Chemical Biology

Volume: 12, P: 282-289
A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth

Ong et al. report how YAP/TAZ and mTORC1 signalling intersect in endothelial cells to regulate nutrient acquisition and vascular growth.

Yu Ting Ong
Jorge Andrade
Michael Potente
ResearchOpen Access20 Jun 2022
Nature Metabolism

Volume: 4, P: 672-682
The Hippo signaling functions through the Notch signaling to regulate intrahepatic bile duct development in mammals

Nan Wu
Quy Nguyen
Haibo Bai
Research05 Jun 2017
Laboratory Investigation

Volume: 97, P: 843-853

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