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Showing 1–3 of 3 results
Advanced filters: Author: Dustin L. McMinn Clear advanced filters

  • Wenzell et al. developed a massively parallel screening platform to interrogate the sensitivity of signal peptides (SPs) to Sec61 inhibitors. The platform revealed how distinct inhibitors achieve sequence-dependent SP discrimination.

    • Nicole A. Wenzell
    • Brian B. Tuch
    • Jack Taunton
    Research
    Nature Chemical Biology
    Volume: 20, P: 1154-1163

  • A selective inhibitor of Sec61 blocks protein entry into the secretory pathway and has therapeutic efficacy in rheumatoid arthritis. A cryo-EM structure of the inhibited Sec61 provides a model for client-selective protein translocation inhibition.

    • Shahid Rehan
    • Dale Tranter
    • Ville O. Paavilainen
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 19, P: 1054-1062