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Showing 1–23 of 23 results
Advanced filters: Author: Dustin R. Allen Clear advanced filters

  • EchoNext, a deep learning model for electrocardiograms trained and validated in diverse health systems, successfully detects many forms of structural heart disease, supporting the potential of artificial intelligence to expand access to heart disease screening at scale.

    • Timothy J. Poterucha
    • Linyuan Jing
    • Pierre Elias
    ResearchOpen Access
    Nature
    Volume: 644, P: 221-230

  • The BRAIN Initiative Cell Census Network has constructed a multimodal cell census and atlas of the mammalian primary motor cortex in a landmark effort towards understanding brain cell-type diversity, neural circuit organization and brain function.

    • Edward M. Callaway
    • Hong-Wei Dong
    • Susan Sunkin
    ResearchOpen Access
    Nature
    Volume: 598, P: 86-102

  • Electron-microscopy data are used to reconstruct the neurons that make up the anterior visual pathway in the Drosophila brain, providing insight into how visual features are encoded to guide navigation.

    • Dustin Garner
    • Emil Kind
    • Sung Soo Kim
    ResearchOpen Access
    Nature
    Volume: 634, P: 181-190

  • FlyWire presents a neuronal wiring diagram of the whole fly brain with annotations for cell types, classes, nerves, hemilineages and predicted neurotransmitters, with data products and an open ecosystem to facilitate exploration and browsing.

    • Sven Dorkenwald
    • Arie Matsliah
    • Meet Zandawala
    ResearchOpen Access
    Nature
    Volume: 634, P: 124-138

  • Durable agonism of NPR1 achieved with a novel investigational monoclonal antibody could mirror the positive hemodynamic changes in blood pressure and heart failure identified in humans with lifelong exposure to NPR1 coding variants.

    • Michael E. Dunn
    • Aaron Kithcart
    • Lori Morton
    ResearchOpen Access
    Nature
    Volume: 633, P: 654-661

  • Jones et al. examine the generalizability of the valence–dominance model of social judgements of faces in 41 countries across 11 world regions. They find evidence of both generalizability and variation, depending on the analytical method.

    • Benedict C. Jones
    • Lisa M. DeBruine
    • Nicholas A. Coles
    Research
    Nature Human Behaviour
    Volume: 5, P: 159-169

  • Managing the interactions and impacts of scaled-up solar energy production will require understanding of the relationships between technological and ecological systems. This Perspective proposes a framework that could help engineer beneficial outcomes from an energy transition.

    • Rebecca R. Hernandez
    • Alona Armstrong
    • Daniel M. Kammen
    Reviews
    Nature Sustainability
    Volume: 2, P: 560-568

  • The Impact of Genomic Variation on Function Consortium is combining single-cell mapping, genomic perturbations and predictive modelling to investigate relationships between human genomic variation, genome function and phenotypes and will provide an open resource to the community.

    • Jesse M. Engreitz
    • Heather A. Lawson
    • Ella K. Samer
    Reviews
    Nature
    Volume: 633, P: 47-57

  • This article aims to make the methodology behind the recent spate of papers reportingin situimmune-cell imaging more accessible to the reader and to highlight potential artefacts so that the reader can analyse the data more critically.

    • Ronald N. Germain
    • Mark J. Miller
    • Michel C. Nussenzweig
    Reviews
    Nature Reviews Immunology
    Volume: 6, P: 497-507

  • Rare variant association data from human genetics combined with in vitro and in vivo functional validation highlight ANGPTL7 as a promising therapeutic target for intraocular pressure reduction, and protection from glaucoma.

    • Kavita Praveen
    • Gaurang C. Patel
    • Giovanni Coppola
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-15

  • In an inter-laboratory study, the authors compare the accuracy and performance of three optical density calibration protocols (colloidal silica, serial dilution of silica microspheres, and colony-forming unit (CFU) assay). They demonstrate that serial dilution of silica microspheres is the best of these tested protocols, allowing precise and robust calibration that is easily assessed for quality control and can also evaluate the effective linear range of an instrument.

    • Jacob Beal
    • Natalie G. Farny
    • Jiajie Zhou
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-29