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Showing 1–4 of 4 results
Advanced filters: Author: Dylan Carney Clear advanced filters

  • One of four papers establishing certain PHD domains as effectors of trimethylated histone H3K4, a chromatin mark generally associated with active transcription.

    The interaction between H3K4me3 and the ING2 PHD domain is enhanced after DNA damage, recruiting the repressive complex to the promoters of proliferation genes.

    • Xiaobing Shi
    • Tao Hong
    • Or Gozani
    Research
    Nature
    Volume: 442, P: 96-99

  • Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

    • Céline Bellenguez
    • Fahri Küçükali
    • Jean-Charles Lambert
    ResearchOpen Access
    Nature Genetics
    Volume: 54, P: 412-436

  • This Consensus Statement discusses the management of asymptomatic individuals with a germline mutation in one of the succinate dehydrogenase (SDHx) genes (SDHA, SDHB, SDHC and SDHD), which encode the four subunits of the SDH enzyme. These individuals are at increased risk of phaeochromocytoma and/or paraganglioma.

    • Laurence Amar
    • Karel Pacak
    • Charlotte Lussey-Lepoutre
    ReviewsOpen Access
    Nature Reviews Endocrinology
    Volume: 17, P: 435-444

  • RAG2, a component of the V(D)J recombinase, has a plant homeodomain (PHD) domain which specifically recognizes histone H3 trimethylated at lysine 4 (H3K4me3). A crystal structure of the complex is presented, and the interaction between RAG2 and H3K4me3 shown to be important for V(D)J recombination in vivo.

    • Adam G. W. Matthews
    • Alex J. Kuo
    • Marjorie A. Oettinger
    Research
    Nature
    Volume: 450, P: 1106-1110