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Showing 1–22 of 22 results
Advanced filters: Author: Dylan J. Taatjes Clear advanced filters

  • Gene activation may involve the formation of a DNA loop that connects enhancer-bound transcription factors with the transcription apparatus at the core promoter. But this process is not well understood. Here, two proteins, mediator and cohesin, are shown to connect the enhancers and core promoters of active genes in embryonic stem cells. These proteins seem to generate cell-type-specific DNA loops linked to the gene expression program of each cell.

    • Michael H. Kagey
    • Jamie J. Newman
    • Richard A. Young
    Research
    Nature
    Volume: 467, P: 430-435

  • The finding that the Mediator protein complex contributes to messenger RNA export from the nucleus in yeast adds to a growing list of roles for the complex in regulating transcriptional processes.

    • Jonathan D. Rubin
    • Dylan J. Taatjes
    News & Views
    Nature
    Volume: 526, P: 199-200

  • RNA polymerase II (Pol II) is globally regulated by Mediator, a large, conformationally flexible protein complex with a variable subunit composition. These biochemical characteristics are fundamental for the ability of Mediator to control processes involved in transcription, including the organization of chromatin architecture and the regulation of Pol II pre-initiation, initiation, re-initiation, pausing and elongation.

    • Benjamin L. Allen
    • Dylan J. Taatjes
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 16, P: 155-166

  • CDK8 is a kinase found in some Mediator complexes and has been implicated in oncogenesis. Now it is shown to be a positive regulator of transcription elongation at immediate early serum response genes, regulating recruitment of elongation factors including P-TEFb.

    • Aaron J Donner
    • Christopher C Ebmeier
    • Joaquín M Espinosa
    Research
    Nature Structural & Molecular Biology
    Volume: 17, P: 194-201

  • While activators must impact the Mediator complex to promote transcription, the mechanisms that underpin this are currently unclear. The effects of p53 domain-binding on transcription and mediator structures now argue that a pocket, similar in size to one previously seen upon SREBP binding, may be a feature of an activated Mediator complex.

    • Krista D Meyer
    • Shih-chieh Lin
    • Dylan J Taatjes
    Research
    Nature Structural & Molecular Biology
    Volume: 17, P: 753-760

  • Analysis of the kinase activity of 300 protein Ser/Thr kinases reveals that the substrate specificity of the kinome is substantially more diverse than expected and is driven extensively by negative selectivity

    • Jared L. Johnson
    • Tomer M. Yaron
    • Lewis C. Cantley
    ResearchOpen Access
    Nature
    Volume: 613, P: 759-766

  • After years of only low-resolution and partial assemblies, the entire human preinitiation complex (PIC), including the large and flexible Mediator and TFIID complexes, has come into focus. Five recent papers from three different research groups have transformed our understanding of transcription initiation by RNA polymerase II.

    • Allison C. Schier
    • Dylan J. Taatjes
    News & Views
    Nature Structural & Molecular Biology
    Volume: 28, P: 540-543

  • Cryo-electron microscopy structures of key intermediates during the sequential assembly of the pre-initiation complex are presented; structures of the closed and open-promoter complexes allow insights into the process of promoter melting.

    • Yuan He
    • Jie Fang
    • Eva Nogales
    Research
    Nature
    Volume: 495, P: 481-486

  • The Mediator complex is an important regulator of RNA polymerase II. This Review discusses recent structural insights into Mediator function and proposes a model that reconciles contradictory data on whether enhancer–promoter communication during transcription is direct or indirect.

    • William F. Richter
    • Shraddha Nayak
    • Dylan J. Taatjes
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 23, P: 732-749

  • The protein TRIM28 is identified as a factor that modulates RNA polymerase II pausing and transcriptional elongation at a large number of mammalian genes. This function is regulated by transcription-coupled phosphorylation of TRIM28 at Ser824.

    • Heeyoun Bunch
    • Xiaofeng Zheng
    • Stuart K Calderwood
    Research
    Nature Structural & Molecular Biology
    Volume: 21, P: 876-883

  • Targeting a post-translational modification of Fas by recombinant Glrx reverses established lung fibrosis in a mouse model of age-related idiopathic pulmonary fibrosis.

    • Vikas Anathy
    • Karolyn G. Lahue
    • Yvonne M. W. Janssen-Heininger
    Research
    Nature Medicine
    Volume: 24, P: 1128-1135

  • RNA polymerase II with a hypophosphorylated C-terminal domain preferentially incorporates into mediator condensates, and with a hyperphosphorylated C-terminal domain into splicing-factor condensates, revealing phosphorylation as a regulatory mechanism in condensate preference.

    • Yang Eric Guo
    • John C. Manteiga
    • Richard A. Young
    Research
    Nature
    Volume: 572, P: 543-548

  • A small-molecule inhibitor of the Mediator-associated kinases CDK8 and CDK19 inhibits growth of acute myeloid leukaemia (AML) cells and induces upregulation of super-enhancer-associated genes with tumour suppressor and lineage-controlling functions; Mediator kinase inhibition therefore represents a promising therapeutic approach for AML.

    • Henry E. Pelish
    • Brian B. Liau
    • Matthew D. Shair
    Research
    Nature
    Volume: 526, P: 273-276

  • A class of long non-coding RNA (lncRNA) with enhancer-like activity is found to associate with the co-activator complex Mediator and promote its genomic association and enzymatic activity; together with Mediator, the lncRNAs also help to maintain the chromosomal architecture of active regulatory elements.

    • Fan Lai
    • Ulf A. Orom
    • Ramin Shiekhattar
    Research
    Nature
    Volume: 494, P: 497-501

  • Rubin et al. introduce transcription factor enrichment analysis (TFEA), a new motif enrichment method specifically aimed at maximizing the informative nature of differential RNA polymerase initiation data. It provides an easy, rigorous, and cost-effective analysis aimed at deciphering the temporal and mechanistic details of complex regulatory networks.

    • Jonathan D. Rubin
    • Jacob T. Stanley
    • Robin D. Dowell
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-15

  • Mediator is a large and structurally dynamic protein complex that is globally required for eukaryotic transcription by RNA polymerase II. In a recent paper published in Cell Research, Wang et al. report for the first time the location of distinct subunits and redefine domains in the S. cerevisiae Mediator complex.

    • Nicholas C Sennett
    • Dylan J Taatjes
    Research Highlights
    Cell Research
    Volume: 24, P: 775-776