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Showing 1–50 of 62 results

Advanced filters: Author: E M Wetzler Clear advanced filters

Development of a targeted BioPROTAC degrader selective for misfolded SOD1

Conventional PROTACs have limited capacity for misfolded proteins. Here, authors develop a BioPROTAC containing an scFv specifically targeting misfolded SOD1, fused to an E3 ligase, and demonstrate a strategy for reducing misfolded SOD1 accumulation.

Christen G. Chisholm
Rachael Bartlett
Justin J. Yerbury
ResearchOpen Access10 Nov 2025
Nature Communications

Volume: 16, P: 1-16
Distinct neurochemical influences on fMRI response polarity in the striatum

The relationship between striatal vascular and neural activity is not fully understood. Here the authors found neuronal activity inadequately explains striatal hemodynamic polarity, challenging classic fMRI interpretations.

Domenic H. Cerri
Daniel L. Albaugh
Yen-Yu Ian Shih
ResearchOpen Access01 Mar 2024
Nature Communications

Volume: 15, P: 1-23
New and Old Immunodeficiencies

Richard E Stiehm
Research01 Jan 1993
Pediatric Research

Volume: 33, P: S2-S8
Tbx1 haploinsufficiency leads to local skull deformity, paraflocculus and flocculus dysplasia, and motor-learning deficit in 22q11.2 deletion syndrome

Neurodevelopmental disorders normally arise from intrinsic brain abnormality. Here the authors show that a motor-learning deficit in 22q11 deletion syndrome may arise from improper development of the skull structure housing a part of the cerebellum.

Tae-Yeon Eom
J. Eric Schmitt
Stanislav S. Zakharenko
ResearchOpen Access05 Dec 2024
Nature Communications

Volume: 15, P: 1-21
New and Old Immunodeficiencies

E Richard Stiehm
Research01 Apr 1993
Pediatric Research

Volume: 33, P: S2-S8
Time-dependent material properties and composition of the nonhuman primate uterine layers through gestation

Daniella M. Fodera
Echo Z. Xu
Kristin M. Myers
ResearchOpen Access02 Jul 2025
Scientific Reports

Volume: 15, P: 1-16
Impaired Surface Membrane Expression of C3bi but Not C3b Receptors on Neonatal Neutrophils

Margaret C Bruce
Jill E Baley
Melvin Berger
Research01 Mar 1987
Pediatric Research

Volume: 21, P: 306-311
3D Mass Spectrometry Imaging Reveals a Very Heterogeneous Drug Distribution in Tumors

S. Giordano
L. Morosi
E. Davoli
ResearchOpen Access14 Nov 2016
Scientific Reports

Volume: 6, P: 1-8
Retinal ganglion cell loss in kinesin-1 cargo Alcadein α deficient mice

Yuki Nakano
Kazuyuki Hirooka
Yoshiaki Kiuchi
ResearchOpen Access03 Mar 2020
Cell Death & Disease

Volume: 11, P: 1-9
554 EVIDENCE FOR THE ROLE OF RIBONUCLEOTIDE REDUCTASE INHIBITION IN ADENOSINE DEAMINASE DEFICIENCY

S H Polmar
E M Wetzler
D W Martin Jr.
Research01 Apr 1978
Pediatric Research

Volume: 12, P: 456
TISSUE ADENOSINE DEAMINASE ACTIVITY IN AN ADENOSINE DEFICIENT-COMBINED IMMUNODEFICIENCY DISEASE PATIENT

Bernard Pollara
William P Schrader
Richard J Pickering
Research01 Apr 1977
Pediatric Research

Volume: 11, P: 492
CHRONIC GRANULOMATOUS DISEASE (CGD) IN A BLACK FAMILY WITH ATYPICAL GENETIC TRANSMISSION

Bruce E Ponce
Catherine U Kyong
Mitchell I Rubin
Research01 Apr 1977
Pediatric Research

Volume: 11, P: 492
SUPPRESSION OF MYELOPOIESIS IN THE SOFT AGAR CULTURE SYSTEM IN A PATIENT WITH PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH) AND APLASTIC ANEMIA (AA)

Norma K C Ramsay
William Krivit
John H Kersey
Research01 Apr 1977
Pediatric Research

Volume: 11, P: 492
558 BINDING OF ¹²³ I-LABELED PROTEASES TO PLASMA PROTEINS IN CYSTIC FIBROSIS

Giovanni Romeo
Joann C Blessing-Moore
Howard Cann
Research01 Apr 1978
Pediatric Research

Volume: 12, P: 456
Drug-Induced Actions on Brain Neurotransmitter Systems and Changes in the Behaviors and Emotions of Depressed Patients

Martin M. Katz
James W. Maas
Peter E. Stokes
Research01 Oct 1994
Neuropsychopharmacology

Volume: 11, P: 89-100
Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS

Lenalidomide, a derivative of thalidomide, is an effective drug for myelodysplastic syndrome; lenalidomide binds the CRL4^CRBN E3 ubiquitin ligase and promotes degradation of casein kinase 1a, on which the malignant cells rely for survival.

Jan Krönke
Emma C. Fink
Benjamin L. Ebert
Research01 Jul 2015
Nature

Volume: 523, P: 183-188
Dorsal raphe to basolateral amygdala corticotropin-releasing factor circuit regulates cocaine-memory reconsolidation

Jobe L. Ritchie
Shuyi Qi
Rita A. Fuchs
Research27 May 2024
Neuropsychopharmacology

Volume: 49, P: 2077-2086
Brain-transportable dipeptides across the blood-brain barrier in mice

Mitsuru Tanaka
Shinya Dohgu
Toshiro Matsui
ResearchOpen Access08 Apr 2019
Scientific Reports

Volume: 9, P: 1-10
Contribution of the different Neisseria gonorrhoeae lipooligosaccharide structural variants to functional responses elicited by GMMA outer membrane vesicles

R. Cuffaro
G. Buffi
F. Carboni
ResearchOpen Access30 Oct 2025
npj Vaccines

Volume: 10, P: 1-12
The Ratios of monounsaturated to saturated phosphatidylcholines in lung adenocarcinoma microenvironment analyzed by Liquid Chromatography-Mass spectrometry and imaging Mass spectrometry

Yusuke Muranishi
Toshihiko Sato
Hiroshi Date
ResearchOpen Access20 Jun 2019
Scientific Reports

Volume: 9, P: 1-10
955 MONOCLONAL ANTI-ACTIN ANTIBODIES BIND TO DIFFERENTIATION ANTIGEN ON NORMAL HUMAN LYMPHOCYTES AND PREVENT REACTIVITY TO MITOGENS

K S Barron
H M Rosenblatt
H T Shearer
Research01 Apr 1985
Pediatric Research

Volume: 19, P: 270
960 DEVELOPMENT OF IMMUNITY IN SEVERE PRIMARY T CELL DEFICIENCY FOLLOWING HAPLOIDENTICAL STEM CELL TRANSPLANTATION

Rebecca H Buckley
Sherrie E Schiff
Frances E Ward
Research01 Apr 1985
Pediatric Research

Volume: 19, P: 270
Long-term Rescue of Photoreceptors in a Rodent Model of Retinitis Pigmentosa Associated with MERTK Mutation

H. Lorach
S. Kang
D. Palanker
ResearchOpen Access27 Jul 2018
Scientific Reports

Volume: 8, P: 1-10
Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice

Ikuo Ogiwara et al. find that nonsense mutations in the gene coding for the voltage-gated sodium channel Nav1.2, SCN2A, cause absence-like seizures in mice. They also find that Nav1.2 haplodeficiency in excitatory, but not in inhibitory, neurons contributes to epileptogenesis.

Ikuo Ogiwara
Hiroyuki Miyamoto
Kazuhiro Yamakawa
ResearchOpen Access19 Jul 2018
Communications Biology

Volume: 1, P: 1-16
Biotechnology in Commercial Mushroom Fermentation

T. E. Tautorus
P. M. Townsley
Reviews01 Aug 1984
Bio/Technology

Volume: 2, P: 696-701
Expression of the Complement Receptors CR1 and CR3 and the Type III Fc_γ Receptor on Neutrophils from Newborn Infants and from Fetuses with Rh Disease

Jeffrey B Smith
Donald E Campbell
Mary Catherine Harris
Research01 Aug 1990
Pediatric Research

Volume: 28, P: 120-126
Machine learning-based classification of mitochondrial morphology in primary neurons and brain

Garrett M. Fogo
Anthony R. Anzell
Thomas H. Sanderson
ResearchOpen Access04 Mar 2021
Scientific Reports

Volume: 11, P: 1-12
MitosRNAs and extreme anoxia tolerance in embryos of the annual killifish Austrofundulus limnaeus

Claire L. Riggs
Steven Cody Woll
Jason E. Podrabsky
ResearchOpen Access24 Dec 2019
Scientific Reports

Volume: 9, P: 1-17
Engineering multi-layered tissue constructs using acoustic levitation

Angela Tait
Peter Glynne-Jones
Donna E. Davies
ResearchOpen Access05 Jul 2019
Scientific Reports

Volume: 9, P: 1-11
Antenatal ureaplasma infection impairs development of the fetal ovine gut in an IL-1-dependent manner

T G A M Wolfs
S G Kallapur
B W Kramer
Research31 Oct 2012
Mucosal Immunology

Volume: 6, P: 547-556
Central Serotonergic Effects of m-Chlorophenylpiperazine (mCPP) among Normal Control Adolescents

Neera Ghaziuddin
Kathy Welch
John Greden
Research16 Dec 2003
Neuropsychopharmacology

Volume: 28, P: 133-139
Long-term follow-up results of alpha-interferon-based regimens in patients with late chronic phase chronic myelogenous leukemia

S Sacchi
HM Kantarjian
M Talpaz
Research01 Oct 1997
Leukemia

Volume: 11, P: 1610-1616
Dissociable Hormonal, Cognitive and Mood Responses to Neuroendocrine Challenge: Evidence for Receptor-Specific Serotonergic Dysregulation in Depressed Mood

WJ Riedel
T Klaassen
HM van Praag
Research22 Aug 2001
Neuropsychopharmacology

Volume: 26, P: 358-367
Enhanced heroin self-administration and distinct dopamine adaptations in female rats

Brianna E. George
Samuel H. Barth
Sara R. Jones
Research26 May 2021
Neuropsychopharmacology

Volume: 46, P: 1724-1733
Results of decitabine therapy in the accelerated and blastic phases of chronic myelogenous leukemia

HM Kantarjian
SM O’Brien
M Talpaz
Research01 Oct 1997
Leukemia

Volume: 11, P: 1617-1620
Amplification and overexpression of the EGF receptor and c-erbB-2 proto-oncogenes in human stomach cancer

NR Lemoine
S Jain
MI Filipe
Research01 Jul 1991
British Journal of Cancer

Volume: 64, P: 79-83
Optimisation of electrotransfer of plasmid into skeletal muscle by pretreatment with hyaluronidase – increased expression with reduced muscle damage

JM McMahon
E Signori
DJ Wells
Research15 Aug 2001
Gene Therapy

Volume: 8, P: 1264-1270
Serotonin and Thermoregulation

Paul J Schwartz
Thomas A Wehr
Dennis L Murphy
Research01 Oct 1995
Neuropsychopharmacology

Volume: 13, P: 105-115
Serotonin Uptake Sites and Serotonin Receptors Are Altered in the Limbic System of Schizophrenics

Jeffrey N. Joyce
Audi Shane
Joel E. Kleinman
Research01 Jun 1993
Neuropsychopharmacology

Volume: 8, P: 315-336
Role of the Dorsomedial Hypothalamus in Mediating the Response to Benzodiazepines on Trial 2 in the Elevated Plus-Maze Test of Anxiety

Sandra E File
Luis E Gonzalez
Rachael Gallant
Research01 Aug 1999
Neuropsychopharmacology

Volume: 21, P: 312-320
Inhibitory effects of the combination of HER-2 antisense oligonucleotide and chemotherapeutic agents used for the treatment of human breast cancer

Antonina S Rait
Kathleen F Pirollo
Esther H Chang
Research30 Oct 2001
Cancer Gene Therapy

Volume: 8, P: 728-739
High-efficiency plasmid gene transfer into dystrophic muscle

H Gollins
J McMahon
D J Wells
Research06 Mar 2003
Gene Therapy

Volume: 10, P: 504-512
Inflammatory lipid sphingosine-1-phosphate upregulates C-reactive protein via C/EBPβ and potentiates breast cancer progression

E-S Kim
Y Cha
A Moon
Research19 Aug 2013
Oncogene

Volume: 33, P: 3583-3593
Different levels of control prevent interferon-γ-inducible HLA-class II expression in human neuroblastoma cells

Michela Croce
Alessandro De Ambrosis
Silvano Ferrini
Research30 Oct 2003
Oncogene

Volume: 22, P: 7848-7857
Cytoplasmic and nuclear localization of the 130 and 160 kDa Bcr proteins

E Laurent
M Talpaz
R Kurzrock
Research02 Nov 2000
Leukemia

Volume: 14, P: 1892-1897
Chimeric rabies SADB19-VSVg-pseudotyped lentiviral vectors mediate long-range retrograde transduction from the mouse spinal cord

L Schoderboeck
S Riad
S M Hughes
Research29 Jan 2015
Gene Therapy

Volume: 22, P: 357-364
Morphine-Induced c-fos mRNA Expression in Striatofugal Circuits: Modulation by Dose, Environmental Context, and Drug History

Susan M Ferguson
Mark J Thomas
Terry E Robinson
Research12 May 2004
Neuropsychopharmacology

Volume: 29, P: 1664-1674
Immunoglobulin derived depositions in the nervous system: novel mass spectrometry application for protein characterization in formalin-fixed tissues

Fausto J Rodriguez
Jeffrey D Gamez
Ahmet Dogan
Research18 Aug 2008
Laboratory Investigation

Volume: 88, P: 1024-1037
A distinctive nuclear morphology in acute myeloid leukemia is strongly associated with loss of HLA-DR expression and FLT3 internal tandem duplication

S J Kussick
D L Stirewalt
B L Wood
Research02 Sept 2004
Leukemia

Volume: 18, P: 1591-1598
Prediction of response and survival in patients with chronic-phase chronic myeloid leukemia treated with omacetaxine mepesuccinate: logistic regression and landmark analyses

M Wetzler
H M Kantarjian
J Cortes
CorrespondenceOpen Access11 Dec 2015
Blood Cancer Journal

Volume: 5, P: e376

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