Fibrosis is a key characteristic of a range of chronic diseases that has been challenging to target with drugs. This Review highlights core pathways active in fibrotic conditions across organs, as well as specific mechanisms and characteristics of fibrotic diseases in the lung, gut, kidney, skin and liver, and provides proposals for strategies to improve the translation of potential antifibrotic therapies.
- Florian Rieder
- Laura E. Nagy
- Marco Prunotto