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Showing 1–10 of 10 results
Advanced filters: Author: E. Moeendarbary Clear advanced filters

  • Glial scars are thought to provide a biochemical and mechanical barrier to neuronal regeneration post-injury, but the mechanical properties of the scars have not been studied in detail. Here the authors perform atomic force microscopy measurements of glial scars from the injured rat cortex and spinal cord, and find that brain tissue softens in response to the injury.

    • Emad Moeendarbary
    • Isabell P. Weber
    • Kristian Franze
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11

  • The mechanobiology of blood brain barrier (BBB) remains underexplored. In this perspective, the authors highlight the emerging importance of mechanical forces in shaping BBB function across development, disease, and ageing. They also argue that integrating biomechanics into BBB research is important for advancing future therapies.

    • Simon Konig
    • Vignesh Jayarajan
    • Emad Moeendarbary
    ReviewsOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Quantifying rapidly progressing three-dimensional forces generated by cells remains a major challenge in mechanobiology. Here, the authors show that combining traction force microscopy with astigmatic imaging permits sensitive out-of-plane force estimation on the second timescale.

    • Di Li
    • Huw Colin-York
    • Marco Fritzsche
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • The field of biogerontology has established itself through significant lines of research in recent decades. However, despite early breakthroughs, progress in understanding the aging process has been slow. To push the field forward, new methodologies and technologies are likely needed to unravel the complexity of aging. This meeting brought together leading scientists and innovators to explore some emerging approaches, presenting groundbreaking advancements in four key sessions, culminating in a panel discussion.

    • Maximilian Unfried
    • Tomas Schmauck-Medina
    • Morten Scheibye-Knudsen
    News & ViewsOpen Access
    npj Aging
    Volume: 11, P: 1-4

  • Gap formation in the vasculature underpins immune and tumour cell infiltration. Here the authors propose a chemo-mechanical model to analyse how feedback between mechanosensitive signalling, active cellular forces and adhesion governs the breakdown, recovery, and integrity of endothelial junctions.

    • Eoin McEvoy
    • Tal Sneh
    • Vivek B. Shenoy
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • In vitro models of actin organization show the formation of vortices, asters and stars. Here Fritzsche et al. show that such actin structures form in living cells in a manner dependent on the Arp2/3 complex but not myosin, and such structures influence membrane architecture but not cortex elasticity.

    • M. Fritzsche
    • D. Li
    • C. Eggeling
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14

  • Sahai and colleagues report that YAP is required for the establishment and function of cancer-associated fibroblasts. They propose that matrix stiffening promotes Src-mediated activation of YAP in fibroblasts, which is necessary for the cancer-associated fibroblast phenotype and further promotes matrix stiffening in a positive feedback loop.

    • Fernando Calvo
    • Nil Ege
    • Erik Sahai
    Research
    Nature Cell Biology
    Volume: 15, P: 637-646

  • Mechanical forces play important roles in cell biology and traction force microscopy (TFM) experiments have enabled quantification of the cell-generated forces when placed on substrates of distinct stiffnesses. Here the authors evaluate the effect of the Poisson’s ratio- one of the main descriptors of the material’s mechanical behaviour together with the Elastic Modulus, in the context of TFM experiments.

    • Yousef Javanmardi
    • Huw Colin-York
    • Emad Moeendarbary
    ResearchOpen Access
    Communications Physics
    Volume: 4, P: 1-10