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Showing 1–2 of 2 results
Advanced filters: Author: E. Murat Tuzcu Clear advanced filters

  • The challenge of predicting potential efficacy of anti-atherosclerotic drugs before the completion of long-term trials with endpoints such as mortality has stimulated efforts to develop intermediate measures of efficacy. Nissen and colleagues describe how intravascular ultrasound can be applied to the serial assessment of atheroma burden in response to treatment, which has resulted in its emergence as a key technology in the evaluation and approval of novel drugs.

    • Stephen J. Nicholls
    • Ilke Sipahi
    • Steven E. Nissen
    Reviews
    Nature Reviews Drug Discovery
    Volume: 5, P: 485-492

  • Since the introduction of transcatheter aortic valve implantation (TAVI) as a treatment for inoperable patients with aortic stenosis >1 decade ago, the range of patients who can benefit from this technology has continued to grow. In this Review, Jones and colleagues discuss the current evidence for TAVI in different patient populations, and describe the differences in design features in currently available valve systems.

    • Brandon M. Jones
    • Amar Krishnaswamy
    • Samir R. Kapadia
    Reviews
    Nature Reviews Cardiology
    Volume: 14, P: 615-626