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MCL1 is an anti-apoptotic protein associated with cancer and therapy resistance. Here, the authors show that MCL1 regulates mTORC1 signalling and metabolism, explaining MCL1-inhibition reported cardiotoxicity, which can be mitigated by dietary leucine supplementation.

This research quantifies hospital admissions in Shanghai for mental and behavioral disorders linked to humid heat, projecting a 68.2% increase by the 2090s under high greenhouse gas emissions and emphasizing the importance of mitigation strategies to reduce future morbidity burdens.

The analysis of the energy spectrum of 36 million tritium β-decay electrons recorded in 259 measurement days within the last 40 eV below the endpoint challenges the Neutrino-4 claim.

Skyrmions are objects with whirled magnetization protected by their topology that can be created by different means, however, without control of their position. Here, the authors present a method exploiting x-rays to create skyrmions at the beam position allowing for creation of artificial skyrmion lattices.

The kisspeptin receptor GPR54 is implicated in the maintenance of mammalian fertility. Kirilov et al.study GPR54 mutant mice and identify a subset of neurons in the brain expressing gonadotropin-releasing hormone as the critical site for kisspeptin action.

Terrestrial ecosystem productivity is widely accepted to be nutrient limited. A series of standardized nutrient addition experiments, carried out on grasslands on five continents, suggests aboveground grassland productivity is commonly limited by multiple nutrients, including potassium and micronutrients.

This flagship study from the European Solve-Rare Diseases Consortium presents a diagnostic framework including bioinformatic analysis of clinical, pedigree and genomic data coupled with expert panel review, leading to 500 new diagnoses in a cohort of 6,000 families with suspected rare diseases.

Alexandre Reymond, Henrik Kaessman and colleagues report a high-resolution survey of copy number variation in mice and assess the impact of such variation on gene expression across multiple tissues and strains. They conclude that CNVs substantially influence global transcription, including long-range cis effects extending up to several hundred kilobases.

Why and how mutations in genes encoding BAF complex components lead to distinct disease entitites remains unresolved. In this study, authors establish the first Smarcb1 mutant mouse model with multiple brain abnormalities recapitulating human Coffin–Siris syndrome and show that one prominent midline abnormality, corpus callosum agenesis, is due to midline glia aberrations.

It is unclear whether terrestrial herbivores are able to consume the extra plant biomass produced under nutrient enrichment. Here the authors test this in grasslands using a globally distributed network of coordinated field experiments, finding that wild herbivore control on grassland production declines under eutrophication.

Ancient DNA analyses reveal that Viking Age migrations from Scandinavia resulted in differential influxes of ancestry to different parts of Europe, and the increased presence of non-local ancestry within Scandinavia.

Eye movements are the most frequent movements that humans make. In this Review, Schütz and Stewart integrate evidence regarding the costs of eye movements and discuss considerations for movement dynamics, timing and the spatial control of saccades.

The vascular stem cell niche regulates the proliferation and differentiation of neural stem cells (NSCs) in the adult subventricular zone. Here the authors identify EGFL7 as a neurovascular regulator of NSCsin vivo; EGFL7-knockout mice show reduced neurogenesis, and exhibit impaired olfactory perception and behaviour.

This study explores apelin receptor’s role in cardiovascular function, identifying residues critical for binding through genetic variants, AlphaFold2 modelling and base editing in cardiomyocytes. Co-crystallization with biased agonist CMF-019 shows a unique binding mode versus endogenous peptides.

Ferromagnetism is observed at ferroelastic domain walls in strontium titanate and its heterostructures with other oxides. Applying strain can reverse the magnetism. This suggests the possibility of device engineering using domain walls.

A NutNet experiment in 57 grasslands across six continents shows that when herbivores are excluded from grasslands with a long coevolutionary history of grazing plant diversity is reduced, while in grasslands without a long grazing history the evolutionary history of the plant species regulates the response of plant diversity.

A NutNet global grassland study finds that leaf N, P and K consistently respond to soil nutrient additions, but leaf morphological traits, such as specific leaf area, are inconsistent indicators of anthropogenic perturbations.

Fe₃GeTe₂, known as FGT, is a van der Waals magnetic material that was recently shown to host magnetic skyrmions. Here, Birch et al using both X-ray and electron microscopy to study the stability of skyrmions in FGT, revealing how the sample history can influence skyrmion formation

Eutrophication has been shown to weaken diversity-stability relationships in grasslands, but it is unclear whether the effect depends on scale. Analysing a globally distributed network of grassland sites, the authors show a positive role of beta diversity and spatial asynchrony as drivers of stability but find that nitrogen enrichment weakens the diversity-stability relationships at different spatial scales.

A prerequisite for using domain walls in logic or sensing devices is a thorough knowledge of the properties and precise control. Here the authors monitor the domain wall motion in curved nanowires by stroboscopic imaging and find a regime of oscillating velocity and spin structure below the Walker breakdown.

Nitrogen mineralisation (N_min), an important index of soil fertility, is often determined in the laboratory, with an uncertain relationship to N_min under field conditions. Here the authors show that combining laboratory measurements with environmental data greatly improves predictions of field N_min at a global scale.

The phase transformation of LiFePO₄/FePO₄ is an intriguing problem in lithium-ion battery research. Here, the authors use scanning transmission X-ray microscopy to reveal in-situ phase evolution of LiFePO₄/FePO₄in a micrometer scale battery cell with well characterised single-crystalline electrodes.

Evidence synthesized from 252 large-herbivore exclusion studies suggests that herbivore-induced change in dominance, independent of site productivity or precipitation, best predicts herbivore effects on biodiversity in grassland and savannah sites.

A genetic factor that encourages this form of farmyard bullying has been identified.

Magnetic domain walls could form the basis for information technology with high storage density, but require comparatively high current densities to be moved by spin torque. Here, the authors demonstrate a radically different approach with perpendicular magnetic field pulses moving domain walls synchronously.

The filamentous fungus expression system Thermothelomyces heterothallica (C1) is a protein expression system that may be useful for large scale antibody production. Here the authors characterise the production of a human monoclonal antibody that neutralises SARS-CoV-2 and compare functional properties in vitro and in animal models to antibodies produced using other methods.

In three dimensional systems with broken bulk inversion symmetry, skyrmions can form extended string-like structures. Here, Birch et al use scanning transmission x-ray microscopy to demonstrate the current induced generation and motion of these three dimensional skyrmion strings.

Small interfering RNAs (siRNAs) can be systemically administered in non-human primates and significantly reduce expression from the mRNA against which they are directed. A therapeutic effect can also be achieved by targeting a microRNA (miRNA). A modified oligonucleotide directed against miR-122 was administered to monkeys, resulting in a reduction in serum cholesterol without detectable toxicity.

Magnetic droplets are a type of non-topological magnetic soliton, which are stabilised and sustained by spin-transfer torques for instance. Without this, they would collapse. Here Ahlberg et al show that by decreasing the applied magnetic field, droplets can be frozen, forming a static nanobubble

Higher-order TCRs have been postulated to maintain high antigen sensitivity and trigger signaling. Huppa and colleagues use various investigative techniques and find exclusively monomeric TCR–CD3 complexes that drive the recognition of antigenic pMHC.

Many applications require hydrogen isotopes and so it is important to develop alternative separation technologies. Here, the authors report a metal-organic framework capable of capturing deuterium from H₂/D₂mixtures, and go on to predict selectivity for isotopologues containing tritium.

How accurate are social scientists in predicting societal change, and what processes underlie their predictions? Grossmann et al. report the findings of two forecasting tournaments. Social scientists’ forecasts were on average no more accurate than those of simple statistical models.

DeepTaskGen uses deep learning to generate synthetic task-based fMRI maps from resting state data, enabling scalable neuroimaging studies. It preserves individual variation and outperforms benchmarks in biomarker and cognitive prediction.

An analysis of skyrmion dynamics at different temperatures and electric drive currents is used to develop a complete description of the skyrmion Hall angle in ferromagnetic multilayers from the creep to the flow regime and illustrates that skyrmion trajectories can be engineered for device applications.

Magnetic skyrmions are thought to possess a tube-like structure in three dimensions, but this has not been directly observed in experiment. Here, Birch et al. report real-space imaging of skyrmion tubes in a lamella of FeGe.

If neutrinos are their own antiparticles, neutrinoless double-β decay of ⁷⁶Ge should occur; a new lower-limit half-life of 5 × 10²⁵ years for this process has now been determined under background-free conditions.

Analyses of data from the UK Biobank reveal different urban living environments that are associated with affective, anxiety and emotional instability symptom groups and mediated by distinct neurological and genetic pathways in adults.

The application of small bursts of an oscillating magnetic field can be used to reverse controllably the gyration direction of a vortex core structure, and hence switch the direction of the out-of-plane vortex core polarization. This raises the possibility of using this core switching scheme as a means of magnetic data storage.

Sub-micrometre spin waves are excited in anisotropic spin textures and they can propagate as 2D plane waves over several micrometres and as 1D waves along curved domain walls.

The creation and annihilation of magnetic vortex–antivortex pairs has been predicted to have a role in magnetic switching in permalloy nanostructures, but has never previously been observed. High-speed X-ray microscopy now enables the evolution and dynamics of this process to be studied in detail.

Brain morphogenesis is an important process contributing to higher-order cognition, however our knowledge about its biological basis is largely incomplete. Here, authors analyzed 118 neuroanatomical parameters in 1,566 mutant mouse lines to identify 198 genes whose disruptions yield neuroanatomical phenotypes

Experiments show that when driven by electric currents, magnetic skyrmions experience transverse motion due to their topological charge — similar to the conventional Hall effect experienced by charged particles in a perpendicular magnetic field.