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Showing 1–8 of 8 results
Advanced filters: Author: Eckhard Hofmann Clear advanced filters

  • [FeFe]-hydrogenases catalyze the conversion of protons and electrons to molecular hydrogen, but upon exposure to oxygen, their catalytic cofactor is irreversibly inactivated. Here, the authors determine the crystal structure of hydrogenase CbA5H and identify a cysteine residue, which acts as a safety cap that shields the active site from oxygen.

    • Martin Winkler
    • Jifu Duan
    • Thomas Happe
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • Transcriptional biosensors represent powerful tools for the screening of vast strain libraries, but the broad ligand specificity of some transcriptional regulators (TRs) can prohibit such applications. Here authors present the engineering of a LysG-based biosensor with a focused ligand specificity to isolate L-histidine-producing strains.

    • Dennis Della Corte
    • Hugo L. van Beek
    • Jan Marienhagen
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • Of the four intermediates in the catalytic cycle of [FeFe]-hydrogenases, the hydride state still has eluded characterization. Here, the authors shift the reaction equilibrium for three hydrogenases and enrich the hydride-bound species, characterizing them using a real-time IR spectroscopic technique.

    • Martin Winkler
    • Moritz Senger
    • Thomas Happe
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-7

  • [FeFe]-hydrogenases catalyze H2-evolution and -oxidation at very high turnover-rates. Here the authors provide experimental evidence for the proposed proton-transfer (PT) pathway by kinetically, spectroscopically, and crystallographically characterizing eleven mutants from the two [FeFe]-hydrogenases CpI and HydA1.

    • Jifu Duan
    • Moritz Senger
    • Martin Winkler
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11

  • Heart failure is a major public health issue but due to our poor disease understanding the current therapies are symptomatic. Here the authors identify Myoscape as a novel cardiac protein regulating membrane localization of the L-type calcium channel and heart's contractile force, thus promising new therapeutic avenues for heart failure.

    • Matthias Eden
    • Benjamin Meder
    • Norbert Frey
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-16

  • Animal models are necessary for the discovery, validation and optimization of novel therapeutics. Here, Matthias Tschöp and colleagues consolidate the key information on the currently available animal models of obesity and diabetes mellitus and highlight the advantages, limitations and important caveats of each of these models.

    • Maximilian Kleinert
    • Christoffer Clemmensen
    • Matthias H. Tschöp
    Reviews
    Nature Reviews Endocrinology
    Volume: 14, P: 140-162

  • Dipali Mhaindarkar et al. examine the functional effects of a salt bridge loss in the active site of glycosyl hydrolase Bg1M-G1, found in the metagenome of a seasonally cold marine habitat. They show that the catalytic efficiency is overall higher with the lost salt bridge, trading off with lower thermal stability.

    • Dipali Mhaindarkar
    • Raphael Gasper
    • Lars I. Leichert
    ResearchOpen Access
    Communications Biology
    Volume: 1, P: 1-11