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Showing 1–2 of 2 results
Advanced filters: Author: Ed Yaworski Clear advanced filters

  • Systemically administered modified siRNAs can be used in monkeys to achieve long-lasting silencing of a gene — previously, this had been established only in mice.

    • Tracy S. Zimmermann
    • Amy C. H. Lee
    • Ian MacLachlan
    Research
    Nature
    Volume: 441, P: 111-114

  • Efficient siRNA delivery remains a key challenge to realizing the full potential of RNAi-based therapeutics. Semple et al. accomplish unprecedented potency for liposome-mediated siRNA delivery by applying rational design to refine an empirically identified cationic lipid widely regarded as the benchmark for use in lipid nanoparticles.

    • Sean C Semple
    • Akin Akinc
    • Michael J Hope
    Research
    Nature Biotechnology
    Volume: 28, P: 172-176