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Showing 1–3 of 3 results
Advanced filters: Author: Eden Whitlock Clear advanced filters

  • Cytokines are key molecules in controlling haematopoiesis that signal via the JAK/STAT pathway. Here the authors present the structures of SOCS1 bound to its JAK1 target as well as in complex with elonginB and elonginC, providing a molecular explanation for the potent JAK- inhibitory activity of SOCS1.

    • Nicholas P. D. Liau
    • Artem Laktyushin
    • Jeffrey J. Babon
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14

  • The inhibitory protein SOCS3 plays a key part in hematopoiesis by regulating signaling induced by specific cytokines. The crystal structure of SOCS3 bound to JAK2 and a fragment of the interleulkin-6 receptor reveals how SOCS3 targets specific receptor–JAK complexes and how it exerts its inhibitory activity by blocking substrate binding.

    • Nadia J Kershaw
    • James M Murphy
    • Jeffrey J Babon
    Research
    Nature Structural & Molecular Biology
    Volume: 20, P: 469-476