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Showing 1–9 of 9 results
Advanced filters: Author: Edgar Meinl Clear advanced filters

  • Increasing evidence supports a role for B cells and antibodies in the pathogenesis of multiple sclerosis (MS). Here, Meinl and colleagues discuss the proinflammatory contribution of B-cell signalling in MS, and consider potential targets of autoantibodies. The B-cell response to various MS therapies is also summarized.

    • Markus Krumbholz
    • Tobias Derfuss
    • Edgar Meinl
    Reviews
    Nature Reviews Neurology
    Volume: 8, P: 613-623

  • MicroRNAs (miRNAs) seem to confer a novel layer of gene regulation, possibly fine-tuning the expression of ≈50% of genes in humans. Dysfunction of these short regulatory RNAs has been noted in various neurological disorders, including Alzheimer disease and Parkinson disease. Here, Junker and colleagues explore the possible involvement of miRNAs in multiple sclerosis, highlighting the therapeutic implications for this disease.

    • Andreas Junker
    • Reinhard Hohlfeld
    • Edgar Meinl
    Reviews
    Nature Reviews Neurology
    Volume: 7, P: 56-59

  • B-cell maturation antigen (BCMA) regulates the survival of B cells and is essential for the maintenance of long-lived plasma cells. Here, the authors show that γ-secretase directly sheds BCMA from the cell surface and therefore regulates the number of plasma cells.

    • Sarah A. Laurent
    • Franziska S. Hoffmann
    • Edgar Meinl
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-12

  • Cerebrospinal fluid (CSF) investigation should be routinely performed in patients with a first clinical event that is suggestive of multiple sclerosis (MS). This Review highlights the value of existing CSF biomarkers in eliminating potential differential diagnoses for MS and understanding the underlying pathophysiology of this condition. The authors also discuss the potential for novel biomarkers that could be used in prognosis.

    • Martin Stangel
    • Sten Fredrikson
    • Hayrettin Tumani
    Reviews
    Nature Reviews Neurology
    Volume: 9, P: 267-276

  • A drug already used to treat Parkinson's disease induces repair of the damage that occurs to the myelin sheath around nerve fibres during multiple sclerosis. The finding offers new therapeutic avenues for this disease. See Article p.327

    • Hartmut Wekerle
    • Edgar Meinl
    News & Views
    Nature
    Volume: 502, P: 314-315

  • Oligodendrocyte damage is a key component of demyelinating diseases. Here, the authors use in vivolight and correlated electron microscopy in EAE mouse models, and find early damage occurs at the myelin sheath before spreading to the oligodendrocyte cell body.

    • Elisa Romanelli
    • Doron Merkler
    • Martin Kerschensteiner
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-10

  • B cells can secrete IL-35 upon activation, and subsequently contribute negatively to the regulation of immunity, such as T-cell-mediated autoimmunity or anti-microbial immunity, and a characterization of these cells raises new questions about possible independent roles for IL-10- and IL-35-expressing plasma cells as regulatory cells.

    • Ping Shen
    • Toralf Roch
    • Simon Fillatreau
    Research
    Nature
    Volume: 507, P: 366-370