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Showing 1–3 of 3 results
Advanced filters: Author: Ediz S. Calay Clear advanced filters

  • Metabolically driven, chronic, low-grade inflammation has a crucial role in the pathogenesis of obesity and type 2 diabetes, and multiple stress-signaling cascades link insulin resistance and the immune response. An approved immunomodulatory drug is now shown to inhibit the kinases IKKε and TBK1, suppress inflammation and improve metabolic homeostasis in mouse models of obesity (pages 313–321).

    • Ediz S. Calay
    • Gökhan S. Hotamisligil
    News & Views
    Nature Medicine
    Volume: 19, P: 265-267

  • Hormonal FABP4 is discovered to be a pivotal regulator of an adipose–beta-cell endocrine axis that coordinates energy status and metabolic organ function, and targeting this axis improved metabolic outcomes.

    • Kacey J. Prentice
    • Jani Saksi
    • Gökhan S. Hotamisligil
    Research
    Nature
    Volume: 600, P: 720-726

  • Nutrition can affect the outcome of infectious diseases through its effects on pathogens and/or host immunity. Here, Mejia et al.show that dietary restriction protects from experimental cerebral malaria in mice through its effects on leptin and mTORC1 in T cells.

    • Pedro Mejia
    • J. Humberto Treviño-Villarreal
    • James R. Mitchell
    Research
    Nature Communications
    Volume: 6, P: 1-13