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Pre-operative stereotactic radiosurgery and peri-operative dexamethasone for resectable brain metastases: a two-arm pilot study evaluating clinical outcomes and immunological correlates

Radiation and steroid dosing can affect the immune composition of brain metastasis (BM). The authors have designed a pilot study of pre-operative stereotactic radiosurgery with low or high dose of peri-operative dexamethasone for resectable brain metastases, here reporting clinical outcomes and characterization of intratumor TCF1+ CD8+ stem-like T cell immune niches in the brain.

Caroline S. Jansen
Meghana S. Pagadala
Zachary S. Buchwald
ResearchOpen Access14 Oct 2024
Nature Communications

Volume: 15, P: 1-15
Mapping the developmental trajectory of human astrocytes reveals divergence in glioblastoma

Sojka et al. analyse the transcriptomic and epigenomic landscape of human astrocyte maturation and identify an epigenetically regulated intermediate state associated with aberrant development in glioblastoma.

Caitlin Sojka
Hsiao-Lin V. Wang
Steven A. Sloan
Research08 Jan 2025
Nature Cell Biology

Volume: 27, P: 347-359
Integrative transcriptomics and network analysis reveals core genes driving meningioma pathogenesis and clinical outcomes

Youssef M Zohdy
Ali M Alawieh
Tomas Garzon-Muvdi
ResearchOpen Access21 Nov 2025
Scientific Reports

Volume: 15, P: 1-10
Author Correction: GL261 luciferase-expressing cells elicit an anti-tumor immune response: an evaluation of murine glioma models

Victoria E. Sanchez
John P. Lynes
Edjah K. Nduom
Amendments and CorrectionsOpen Access04 Apr 2022
Scientific Reports

Volume: 12, P: 1
GL261 luciferase-expressing cells elicit an anti-tumor immune response: an evaluation of murine glioma models

Victoria E. Sanchez
John P. Lynes
Edjah K. Nduom
ResearchOpen Access03 Jul 2020
Scientific Reports

Volume: 10, P: 1-11

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Pre-operative stereotactic radiosurgery and peri-operative dexamethasone for resectable brain metastases: a two-arm pilot study evaluating clinical outcomes and immunological correlates

Mapping the developmental trajectory of human astrocytes reveals divergence in glioblastoma

Integrative transcriptomics and network analysis reveals core genes driving meningioma pathogenesis and clinical outcomes

Author Correction: GL261 luciferase-expressing cells elicit an anti-tumor immune response: an evaluation of murine glioma models

GL261 luciferase-expressing cells elicit an anti-tumor immune response: an evaluation of murine glioma models

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