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Nature Communications (2)
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Showing 1–4 of 4 results

Advanced filters: Author: Edouard Couvreu de Deckersberg Clear advanced filters

1q gain bypasses the selective barrier against aneuploidy in RPE differentiation via wild-type co-culture rescue

Aneuploidy impacts differentiation and threatens the safety of stem cell therapies. Here, the authors show that mosaic aneuploidies are eliminated during RPE differentiation, except 1q gain, which is rescued by co-culture through paracrine signals.

Edouard Couvreu de Deckersberg
Yingnan Lei
Claudia Spits
ResearchOpen Access25 Nov 2025
Nature Communications

Volume: 16, P: 1-15
Children born after assisted reproduction more commonly carry a mitochondrial genotype associating with low birthweight

Assisted reproduction increases low birthweight risk in children. This study finds a mitochondrial DNA genotype that is more common in ART children, associates to birthweight and that is linked to maternal ageing and to ovarian stimulation.

Joke Mertens
Florence Belva
Claudia Spits
ResearchOpen Access09 Feb 2024
Nature Communications

Volume: 15, P: 1-16
Gain of 1q confers an MDM4-driven growth advantage to undifferentiated and differentiating hESC while altering their differentiation capacity

Nuša Krivec
Edouard Couvreu de Deckersberg
Claudia Spits
ResearchOpen Access21 Nov 2024
Cell Death & Disease

Volume: 15, P: 1-14
Endogenous suppression of WNT signalling in human embryonic stem cells leads to low differentiation propensity towards definitive endoderm

Dominika Dziedzicka
Mukul Tewary
Mieke Geens
ResearchOpen Access17 Mar 2021
Scientific Reports

Volume: 11, P: 1-14