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Showing 1–7 of 7 results
Advanced filters: Author: Edward J. Brignole Clear advanced filters

  • Structure of human nuclear pore complex in its cellular environment reveals a substantially dilated central channel and shows that its nucleoplasmic and cytoplasmic rings restrict channel dimensions and create membrane asymmetry at the inner ring.

    • Anthony P. Schuller
    • Matthias Wojtynek
    • Thomas U. Schwartz
    ResearchOpen Access
    Nature
    Volume: 598, P: 667-671

  • Two-dimensional MOFs can possess porosity and electrical conductivity but are difficult to grow as single crystals. Here, by balancing in-plane and out-of-plane interactions, single crystals of sizes up to 200 µm are grown, allowing in-plane transport measurements and atomic-resolution analysis.

    • Jin-Hu Dou
    • Maxx Q. Arguilla
    • Mircea Dincă
    Research
    Nature Materials
    Volume: 20, P: 222-228

  • Cryo-electron microscopy and biochemical analyses of the GATOR1 protein complex reveal that two binding modes underpin its ability to regulate Rag GTPases as a GTPase-activating protein for RAGA.

    • Kuang Shen
    • Rick K. Huang
    • David M. Sabatini
    Research
    Nature
    Volume: 556, P: 64-69

  • The 3D structure of the human nutrient-sensing complex GATOR2 is resolved using cryo-electron microscopy.

    • Max L. Valenstein
    • Kacper B. Rogala
    • David M. Sabatini
    Research
    Nature
    Volume: 607, P: 610-616

  • Fatty acid synthase is composed by several catalytic domains that work in sequence, with reaction intermediates being transferred between them. Single-particle EM analysis of different catalytic mutants of rat FAS imaged in the presence of substrates reveals the domains' movements during the reaction cycle.

    • Edward J Brignole
    • Stuart Smith
    • Francisco J Asturias
    Research
    Nature Structural & Molecular Biology
    Volume: 16, P: 190-197

  • Torsins are unusual AAA + ATPases of unknown function that reside in the endoplasmic reticulum of all animals. Here the authors report that TorsinA forms tubular helical filaments with an unusual periodicity and that filamentous TorsinA directly interacts with membranes to form tubular protrusions.

    • F. Esra Demircioglu
    • Weili Zheng
    • Thomas U. Schwartz
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12