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Mechanism of RPA phosphocode priming and tuning by CDK1/WEE1 signaling circuit

RPA is an essential ssDNA binding protein. Here, authors uncover a phosphosite on RPA70 and show that the RPA70 and RPA32 subunits cooperate through a phosphocode to reconfigure RPA domains. This suggests a common mode of reciprocal regulation of RPA and kinases during G2/M phase of cell cycle.

Poonam Roshan
Vikas Kaushik
Sofia Origanti
ResearchOpen Access09 Dec 2025
Nature Communications

Volume: 17, P: 1-19
Mechanism of Rad51 filament formation by Rad52 and Rad55-Rad57 in homologous recombination

The mediator protein Rad52 promotes Rad51 binding onto RPA-coated DNA to initiate homologous recombination. Here, the authors show that Rad52 sorts Rad51 into monomers and stacks the complex on to the ss-dsDNA junction. The Rad55-Rad57 paralog then promotes extension of the Rad51 filament.

Jaigeeth Deveryshetty
Ayush Mistry
Edwin Antony
ResearchOpen Access21 Jul 2025
Nature Communications

Volume: 16, P: 1-17
Cryo-EM captures the coordination of asymmetric electron transfer through a di-copper site in DPOR

CryoEM snapshots of the nitrogenase-like DPOR protein complex captured during turnover reveal that asymmetric conformational changes, substrate recognition, and an interplay between copper and iron sulfur metalloclusters is required for electron transfer.

Rajnandani Kashyap
Natalie Walsh
Edwin Antony
ResearchOpen Access24 Apr 2025
Nature Communications

Volume: 16, P: 1-17
Rtt105 regulates RPA function by configurationally stapling the flexible domains

The single stranded DNA binding protein RPA coordinates DNA metabolism using multiple protein and DNA interaction domains. Here, the authors show that the chaperone-like protein Rtt105 staples RPA domains to prevent untimely protein interactions.

Sahiti Kuppa
Jaigeeth Deveryshetty
Edwin Antony
ResearchOpen Access02 Sept 2022
Nature Communications

Volume: 13, P: 1-16
Yeast Rad52 is a homodecamer and possesses BRCA2-like bipartite Rad51 binding modes

Mediator proteins such as BRCA2 and Rad52 direct formation of Rad51 filaments in Homologous Recombination. Here, the authors present cryoEM structures of Saccharomyces cerevisiae Rad52 revealing a homodecamer and Rad51 binding to two regions in Rad52.

Jaigeeth Deveryshetty
Rahul Chadda
Edwin Antony
ResearchOpen Access05 Oct 2023
Nature Communications

Volume: 14, P: 1-16
An Aurora B-RPA signaling axis secures chromosome segregation fidelity

RPA is a master coordinator of DNA metabolism. Here, authors uncover that RPA is regulated by an Aurora B-signaling circuit that is critical for chromosome segregation in mitosis. Distinct phosphorylation of RPA70 modulates accessibility of RPA domains.

Poonam Roshan
Sahiti Kuppa
Sofia Origanti
ResearchOpen Access25 May 2023
Nature Communications

Volume: 14, P: 1-19
Dynamics and selective remodeling of the DNA-binding domains of RPA

A combination of bulk and single-molecule fluorescence analysis reveals the choreography of binding and rearrangement of individual DNA-binding domains of RPA during homologous recombination.

Nilisha Pokhrel
Colleen C. Caldwell
Edwin Antony
Research04 Feb 2019
Nature Structural & Molecular Biology

Volume: 26, P: 129-136
Whole-genome sequencing of a sporadic primary immunodeficiency cohort

Whole-genome sequencing analysis of individuals with primary immunodeficiency identifies new candidate disease-associated genes and shows how the interplay between genetic variants can explain the variable penetrance and complexity of the disease.

James E. D. Thaventhiran
Hana Lango Allen
Kenneth G. C. Smith
Research06 May 2020
Nature

Volume: 583, P: 90-95
3D genome mapping identifies subgroup-specific chromosome conformations and tumor-dependency genes in ependymoma

Ependymoma is a tumor of the brain or spinal cord with the two most common and aggressive types mainly occurring in children. Here the authors employ 3D genomics and epigenomics to reveal targets for aggressive ependymoma tumors in children.

Konstantin Okonechnikov
Aylin Camgöz
Lukas Chavez
ResearchOpen Access21 Apr 2023
Nature Communications

Volume: 14, P: 1-16
Srs2 prevents Rad51 filament formation by repetitive motion on DNA

Srs2 is a DNA helicase and single-stranded DNA translocase that prevents homologous recombination by dismantling Rad51 filaments. Qiu et al.use single-molecule techniques to describe Rad51 filament formation and show that Srs2 displays repetitive activity on single-stranded DNA, which prevents re-formation of Rad51 filaments after dismantling.

Yupeng Qiu
Edwin Antony
Sua Myong
Research13 Aug 2013
Nature Communications

Volume: 4, P: 1-10
A structural and dynamic model for the assembly of Replication Protein A on single-stranded DNA

Replication Protein A (RPA) coats single stranded DNA (ssDNA) generated during DNA recombination, replication and repair. Here the authors present a structural model suggesting how RPA’s DNA-binding domains promote cooperative assembly of multiple RPAs on long ssDNA.

Luke A. Yates
Ricardo J. Aramayo
Xiaodong Zhang
ResearchOpen Access21 Dec 2018
Nature Communications

Volume: 9, P: 1-14
MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis

Mixed lineage kinase domain-like (MLKL) is the terminal protein in the pro-inflammatory necroptotic cell death program. Here the authors show that MLKL trafficking and plasma membrane accumulation are crucial necroptosis checkpoints, and that accumulation of phosphorylated MLKL at intercellular junctions promotes necroptosis.

Andre L. Samson
Ying Zhang
James M. Murphy
ResearchOpen Access19 Jun 2020
Nature Communications

Volume: 11, P: 1-17
Whole-genome sequencing of patients with rare diseases in a national health system

Whole-genome sequencing and phenotype data sharing are introduced in a national health system to streamline diagnosis and to discover coding and non-coding variants that cause rare diseases.

Ernest Turro
William J. Astle
Willem H. Ouwehand
Research24 Jun 2020
Nature

Volume: 583, P: 96-102
Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort

James E. D. Thaventhiran
Hana Lango Allen
Kenneth G. C. Smith
Amendments and Corrections17 Jul 2020
Nature

Volume: 584, P: E2
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Munib Mesinovic
Xin Ci Wong
David Zucman
ResearchOpen Access16 Jul 2024
Scientific Reports

Volume: 14, P: 1-43
Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data

James H. R. Farmery
Mike L. Smith
Andy G. Lynch
ResearchOpen Access22 Jan 2018
Scientific Reports

Volume: 8, P: 1-17
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Ali Abbas
Sheryl Ann Abdukahil
Luis Felipe Reyes
ResearchOpen Access30 Jul 2022
Scientific Data

Volume: 9, P: 1-22
Publisher Correction: Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data

James H. R. Farmery
Mike L. Smith
Andy G. Lynch
Amendments and CorrectionsOpen Access03 Sept 2018
Scientific Reports

Volume: 8, P: 1-4

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