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Showing 1–2 of 2 results
Advanced filters: Author: Edwin Willemstein Clear advanced filters

  • While the biological roles of ubiquitin chains are well studied, little is known about the functions of SUMO polymers. Here, the authors identify poly-SUMOylation substrates and provide evidence that SUMO polymers regulate the accumulation of CCAN subunits at chromatin and centromeres.

    • Frauke Liebelt
    • Nicolette S. Jansen
    • Alfred C. O. Vertegaal
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-18

  • Signal transduction by small ubiquitin-like modifier (SUMO) is important for cell cycle progression. Here the authors show that SUMOylation regulates the APC/C complex, a master orchestrator of metaphase to anaphase transition, with consequences for mitotic progression.

    • Karolin Eifler
    • Sabine A. G. Cuijpers
    • Alfred C. O. Vertegaal
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15