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Nature Metabolism (1)

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LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes

LONP1, whose expression is downregulated in islets from donors with type 2 diabetes, is vital to mediate efficient mitochondrial protein folding, thus preventing proteotoxicity and promoting islet β cell survival and function.

Jin Li
Yamei Deng
Scott A. Soleimanpour
ResearchOpen Access21 Jul 2025
Nature Metabolism

Volume: 7, P: 1570-1592

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LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes

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