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Showing 1–7 of 7 results
Advanced filters: Author: Egor Marin Clear advanced filters

  • The Na+-pumping KR2 rhodopsin from Krokinobacter eikastus is a light-driven non-proton cation pump whose mechanism of pumping remains to be understood. Here authors solved crystal structures of the O-intermediate state of the pentameric form of KR2 and its D116N and H30A mutants, which sheds light on the mechanism of non-proton cation light-driven pumping.

    • Kirill Kovalev
    • Roman Astashkin
    • Valentin Gordeliy
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • S1P5 is a sphingosine-1-phosphate (S1P) receptor implicated in immune and neurodegenerative disorders. Here, authors report a crystal structure of the S1P5 receptor in complex with a selective inverse agonist, revealing an allosteric subpocket and shedding light on inverse agonism in S1P receptors.

    • Elizaveta Lyapina
    • Egor Marin
    • Vadim Cherezov
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • Cysteinyl leukotriene G protein-coupled receptors CysLT1 and CysLT2 regulate pro-inflammatory responses associated with allergic disorders. Here, authors describe four crystal structures of CysLT2R in complex with three dual CysLT1R/CysLT2R antagonists, which shed light on CysLTR ligand selectivity.

    • Anastasiia Gusach
    • Aleksandra Luginina
    • Vadim Cherezov
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-9

  • Proteorhodopsins act as light-driven outward proton pumps mainly at neutral and alkaline pH, however, mirror proteorhodopsins are known to operate only at acidic pH. Here, the authors report the detailed structural and functional characterization of pH mirror proteorhodopsin SpaR as well as its diverse biological roles.

    • Ivan S. Okhrimenko
    • Kirill Kovalev
    • Valentin I. Gordeliy
    ResearchOpen Access
    Communications Chemistry
    Volume: 6, P: 1-16