Martin-Valiente, Du et al. generate a zebrafish model of vein of Galen aneurysm, reproducing the disease’s structural features and revealing its developmental origin. By pharmacologically targeting MAPK and PI3K signaling pathways in mutant models, they restore normal fusion of precursor blood vessels in existing malformations.
- Edwige Martin-Valiente
- Yao Du
- Nicolas Baeyens
