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Autologous HIV-specific T cell therapy targeting conserved epitopes is well-tolerated in six adults with HIV: an open-label, single-arm phase 1 study

While anti-retroviral therapy (ART) helps contain HIV, whether adoptive T cell therapy further improve the prognosis is unclear. Here the authors conduct an open-label, single-arm phase 1 study to assess the safety (primary outcome) and characteristic (secondary outcome) of autologous, HIV-specific T cell therapy to find it safe to warrant further efficacy assessment.

Danielle K. Sohai
Michael D. Keller
Catherine M. Bollard
ResearchOpen Access15 May 2025
Nature Communications

Volume: 16, P: 1-15
Particle-associated denitrification is the primary source of N₂O in oxic coastal waters

Incomplete denitrification associated with the micro-niche of marine particles, instead of nitrification as previously assumed, is a major source of N₂O in the turbid coastal waters, even though the water is well-oxygenated.

Xianhui S. Wan
Hua-Xia Sheng
Shuh-Ji Kao
ResearchOpen Access13 Dec 2023
Nature Communications

Volume: 14, P: 1-13
Substrate regulation leads to differential responses of microbial ammonia-oxidizing communities to ocean warming

Microbial ammonia oxidation is important in marine nutrient cycling and greenhouse gas dynamics, but the responses to ocean warming are unclear. Here coast to open ocean incubations show that projected year 2100 temperatures might be too hot for these microbes in oligotrophic regions to handle, but may facilitate oxidation rates in coastal waters.

Zhen-Zhen Zheng
Li-Wei Zheng
Shuh-Ji Kao
ResearchOpen Access14 Jul 2020
Nature Communications

Volume: 11, P: 1-10
Warming stimulates sediment denitrification at the expense of anaerobic ammonium oxidation

Nitrogen removal occurs primarily through microbially mediated denitrification, which produces the GHG N₂O, and anaerobic ammonium oxidation (anammox), which does not. Warming stimulates denitrification relative to annamox in subtropical sediments, indicating that warming could lead to greater N₂O production.

Ehui Tan
Wenbin Zou
Shuh-ji Kao
Research23 Mar 2020
Nature Climate Change

Volume: 10, P: 349-355

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Autologous HIV-specific T cell therapy targeting conserved epitopes is well-tolerated in six adults with HIV: an open-label, single-arm phase 1 study

Particle-associated denitrification is the primary source of N2O in oxic coastal waters

Substrate regulation leads to differential responses of microbial ammonia-oxidizing communities to ocean warming

Warming stimulates sediment denitrification at the expense of anaerobic ammonium oxidation

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Particle-associated denitrification is the primary source of N₂O in oxic coastal waters