Nature Search

Functional EGF receptors are present on mouse embryo tissues

Eileen D. Adamson
M. Jane Deller
Joseph B. Warshaw
Research25 Jun 1981
Nature

Volume: 291, P: 656-659
Circulating KRAS G12D but not G12V is associated with survival in metastatic pancreatic ductal adenocarcinoma

ctDNA is a known poor prognostic factor for multiple cancer types, but variant-specificity is unknown. Here, the authors show variant-specific association of ctKRAS levels with survival in previously untreated metastatic pancreatic ductal adenocarcinoma patients in multiple cohorts.

Jacob E. Till
Lee McDaniel
Erica L. Carpenter
ResearchOpen Access09 Jul 2024
Nature Communications

Volume: 15, P: 1-12
Crystal structure of the SALL4–pomalidomide–cereblon–DDB1 complex

The structure of the second zinc finger of SALL4 in complex with pomalidomide, cereblon and DDB1 reveals the unique details of SALL4 recruitment, providing insights for rational design of cereblon-binding drugs with reduced teratogenic risk.

Mary E. Matyskiela
Thomas Clayton
Philip P. Chamberlain
Research06 Apr 2020
Nature Structural & Molecular Biology

Volume: 27, P: 319-322
GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis

The aspartate aminotransaminase GOT1 is important for maintaining redox balance. Here, the authors show that inhibition of GOT1 in pancreatic cancer cells leads to cell death via ferroptosis.

Daniel M. Kremer
Barbara S. Nelson
Costas A. Lyssiotis
ResearchOpen Access11 Aug 2021
Nature Communications

Volume: 12, P: 1-13
Uridine-derived ribose fuels glucose-restricted pancreatic cancer

A metabolite screen of pancreatic cells shows that pancreatic cancer cells metabolize uridine-derived ribose via UPP1, supporting redox balance, survival and proliferation.

Zeribe C. Nwosu
Matthew H. Ward
Costas A. Lyssiotis
ResearchOpen Access17 May 2023
Nature

Volume: 618, P: 151-158
Multimodal mapping of the tumor and peripheral blood immune landscape in human pancreatic cancer

Using single-cell RNA sequencing, CyTOF and multiplex immunohistochemistry, Steele et al. survey the immune landscape in pancreatic cancers, adjacent tissue and blood, observing heterogeneous immune checkpoint receptor expression within patients.

Nina G. Steele
Eileen S. Carpenter
Marina Pasca di Magliano
Research26 Oct 2020
Nature Cancer

Volume: 1, P: 1097-1112
Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

A randomized trial in patients hospitalized with COVID-19 showed no benefit and potentially increased harm associated with the use of convalescent plasma, with subgroup analyses suggesting that the antibody profile in donor plasma is critical in determining clinical outcomes.

Philippe Bégin
Jeannie Callum
Donald M. Arnold
ResearchOpen Access09 Sept 2021
Nature Medicine

Volume: 27, P: 2012-2024
Reply to: Concerns about estimating relative risk of death associated with convalescent plasma for COVID-19

Philippe Bégin
Jeannie Callum
Donald M. Arnold
Research10 Jan 2022
Nature Medicine

Volume: 28, P: 53-58
Author Correction: Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

Philippe Bégin
Jeannie Callum
Donald M. Arnold
Amendments and CorrectionsOpen Access12 Jan 2022
Nature Medicine

Volume: 28, P: 212
Hypoxia promotes an inflammatory phenotype of fibroblasts in pancreatic cancer

Ashley M. Mello
Tenzin Ngodup
Kyoung Eun Lee
ResearchOpen Access15 Sept 2022
Oncogenesis

Volume: 11, P: 1-9

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Functional EGF receptors are present on mouse embryo tissues

Circulating KRAS G12D but not G12V is associated with survival in metastatic pancreatic ductal adenocarcinoma

Crystal structure of the SALL4–pomalidomide–cereblon–DDB1 complex

GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis

Uridine-derived ribose fuels glucose-restricted pancreatic cancer

Multimodal mapping of the tumor and peripheral blood immune landscape in human pancreatic cancer

Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

Reply to: Concerns about estimating relative risk of death associated with convalescent plasma for COVID-19

Author Correction: Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

Hypoxia promotes an inflammatory phenotype of fibroblasts in pancreatic cancer

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