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Showing 1–2 of 2 results
Advanced filters: Author: Ekaterina Jalomo-Khayrova Clear advanced filters

  • This study identifies AcuB as a conserved inhibitor of the deacetylase AcuC in bacteria. AcuB directly suppresses AcuC activity, and this inhibition is enhanced the alarmone diadenosine tetraphosphate, linking stress signaling to acetylation control.

    • Liujuan Zheng
    • Megan K. M. Young
    • Gert Bange
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-15

  • Here the authors investigate the regulatory mechanisms of acetyl-CoA (Ac-CoA) biosynthesis in Bacillus subtilis, probing the interaction between acetyl-CoA synthetase (AcsA) and acetyltransferase (AcuA). They capture a stable AcsA-AcuA complex that inhibits AcsA activity in the absence of Ac-CoA.

    • Liujuan Zheng
    • Yifei Du
    • Gert Bange
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11