Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–11 of 11 results
Advanced filters: Author: Ekaterina Legchenko Clear advanced filters

  • Reperfusion injury following myocardial ischemia is aggravated by inflammation and platelet–neutrophil complex formation. Here the authors show that semaphorin 7A binds to platelet GPIb, enhancing platelet–neutrophil interaction and increasing post-ischemic myocardial tissue injury, and that blockage of semaphorin 7A is protective.

    • David Köhler
    • Tiago Granja
    • Peter Rosenberger
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • Hansmann et al. show that serial intravascular infusions of conditioned media produced by allogenic umbilical cord mesenchymal stem cells markedly improved the clinical features of a young child with severe pulmonary arterial hypertension. The multi-omic approach analyzing the transcriptome and the proteome of these stem cells isolated from four donors provides initial insight into their beneficial paracrine function.

    • Georg Hansmann
    • Philippe Chouvarine
    • Ralf Hass
    ResearchOpen Access
    Nature Cardiovascular Research
    Volume: 1, P: 568-576

  • A study of SARS-CoV-2 variants examining their transmission, infectivity, and potential resistance to therapies provides insights into the biology of the Delta variant and its role in the global pandemic.

    • Petra Mlcochova
    • Steven A. Kemp
    • Ravindra K. Gupta
    ResearchOpen Access
    Nature
    Volume: 599, P: 114-119

  • Sera from vaccinated individuals and some monoclonal antibodies show a modest reduction in neutralizing activity against the B.1.1.7 variant of SARS-CoV-2; but the E484K substitution leads to a considerable loss of neutralizing activity.

    • Dami A. Collier
    • Anna De Marco
    • Ravindra K. Gupta
    Research
    Nature
    Volume: 593, P: 136-141

  • Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

    • Steven A. Kemp
    • Dami A. Collier
    • Ravindra K. Gupta
    Research
    Nature
    Volume: 592, P: 277-282

  • Individuals over eighty years of age are less likely to mount a good immune response against SARS-CoV-2 (measured by neutralization titres) after the first dose of the BNT162b2 mRNA vaccine, but achieve good neutralization after the second dose.

    • Dami A. Collier
    • Isabella A. T. M. Ferreira
    • Ravindra K. Gupta
    ResearchOpen Access
    Nature
    Volume: 596, P: 417-422

  • Transcriptomic and proteomic profiling of blood samples from individuals with COVID-19 reveals immune cell and hematopoietic progenitor cell alterations that are differentially associated with disease severity.

    • Emily Stephenson
    • Gary Reynolds
    • Muzlifah Haniffa
    ResearchOpen Access
    Nature Medicine
    Volume: 27, P: 904-916

  • The spike protein of the Omicron variant of SARS-CoV-2 has a higher affinity for ACE2 than Delta, and a marked change in its antigenicity increases Omicron’s evasion of therapeutic and vaccine-elicited neutralizing antibodies.

    • Bo Meng
    • Adam Abdullahi
    • Ravindra K. Gupta
    ResearchOpen Access
    Nature
    Volume: 603, P: 706-714

  • The SARS-CoV-2 spike glycoprotein is flexible, and its receptor-binding domain (RBD) fluctuates between open and closed conformations. Disulfide bonds are engineered into the spike ectodomain to lock the RBD in the closed state, leading to a construct with high thermostability.

    • Xiaoli Xiong
    • Kun Qu
    • John A. G. Briggs
    Research
    Nature Structural & Molecular Biology
    Volume: 27, P: 934-941