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Advanced filters: Author: Ekkehard M. Kasper Clear advanced filters

Autism gene Ube3a and seizures impair sociability by repressing VTA Cbln1

Increasing expression of the autism-associated gene Ube3a, either alone or in combination with seizures, not only impairs sociability in mice but also reduces expression of the synaptic organizer Cbln1 in the ventral tegmental area, thus weakening glutamatergic transmission.

Vaishnav Krishnan
David C. Stoppel
Matthew P. Anderson
Research15 Mar 2017
Nature

Volume: 543, P: 507-512
BRD4 prevents the accumulation of R-loops and protects against transcription–replication collision events and DNA damage

In order to avoid transcription-replication conflicts (TRCs) on shared DNA templates, cell must maintain strict spatiotemporal co-ordination of transcription with replication. Here the authors uncover a role for BRD4 in preventing TRCs and DNA damage checkpoint signaling in oncogenic cells.

Fred C. Lam
Yi Wen Kong
Michael B. Yaffe
ResearchOpen Access14 Aug 2020
Nature Communications

Volume: 11, P: 1-20
Identification of regulatory variants associated with genetic susceptibility to meningococcal disease

Lisa Borghini
Eileen Png
Peter Schermann
ResearchOpen Access06 May 2019
Scientific Reports

Volume: 9, P: 1-15

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